In a traditionally adjacent field of study, RNA represents another biopolymer that is central to all known life. While the building blocks of RNA are canonically limited to four bases, post-transcriptional modifications (PTMs) can dramatically expand the chemical diversity of RNA, with >100 PTMs having been identified (Machnicka et al., 2013; Nachtergaele and He, 2016; Frye et al., 2018). It is therefore not surprising that the cellular role for RNA is more complex than that of a simple messenger. For instance, RNAs function as scaffolds, molecular decoys, enzymes, and network regulators across the nucleus and cytosol (Cech and Steitz, 2014; Sharp, 2009; Wang and Chang, 2011). With the exception of a few monosaccharide-based tRNA modifications (Kasai et al., 1976; Okada et al., 1977), there has been so far no evidence of a direct linkage between RNA and glycans in nature.