Natural products chemistry is an exciting and diverse field within the chemical sciences that focuses on the identification, function determination, and applications of compounds produced in nature. Our laboratory, the Natural Products Discovery Group (NPDG), specializes in investigating the intriguing biomolecules produced by fungi to understand their natural functions and discover ways these compounds can be translated into new medicines and valuable organic materials. To support these studies, the NPDG has assembled one of the largest natural-product-discovery-focused collections of fungi in academia with roughly 88,000 fungal isolates derived from every major biome in the USA. Extracts selectively enriched for natural products have been prepared from each fungus, enabling the rapid testing of our unique fungal-derived chemistry for uses covering human health and disease, agriculture, novel biomaterials, and more.