His research laboratory is physically located in Lausanne in the Agora Cancer Research Center, which assembles interdisciplinary research groups to translate advances in cancer research to the clinic. His research focuses on uncovering how the immune system controls cancer and other diseases, and how it can be harnessed for therapy. Pittet’s work has identified how cancers are regulated by various immune cells, including cytotoxic T cells, regulatory T cells, macrophages, monocytes, neutrophils, and dendritic cells. These cells are considered as drug targets in cancer immunotherapy.