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职业迁徙
个人简介
Our primary interests are in understanding the molecular underpinnings of vascular disease as well as assessing disease risk. We use a wide range of biochemical, molecular and physiological techniques to make primary observations in cell systems as well as preclinical models. Furthermore, we continue to extend our findings to human subjects in order to confirm their clinical applicability. Current research projects include:
Mechanisms regulating atherosclerosis and abdominal aortic aneurysm disease: While single genes can have dramatic effects in cellular biology, it is becoming increasingly clear that vascular disease (and health) is regulated by the coordinated expression of gene cassettes or pathways. By monitoring expression patterns of the entire genome simultaneously, we can begin to identify networks of genes that work in concert to affect disease progression. Moreover, this approach can often implicate specific nexus genes that are at the center of larger networks and/or participate in multiple pathways. Additionally, we are investigating the role microRNAs, a newly discovered class of small RNA molecues, in orchestrating the activity of multiple genes during the course of disease.
Role of insulin resistance: Reduced activity of the endogenous hormone, insulin, is now recognized as a cardinal feature of type 2 diabetes and an independent risk factor for cardiovascular disease. We have investigated the effects of insulin resistance in several tissues and have recently focused our attention on adipose tissue biology and how it relates to CVD. Long known as a storage vehicle for excess calories, the fat cell is now recognized to be a factory of different products that can not only affect local activity, but can circulate in the blood as hormones and regulate many biological processes. For example, we have recently reported that the novel hormone, apelin, is produced by fat tissue and has important effects upon insulin resistance, obesity and diabetes, all of which have significant implications for cardiovascular disease.
Mechanisms regulating atherosclerosis and abdominal aortic aneurysm disease: While single genes can have dramatic effects in cellular biology, it is becoming increasingly clear that vascular disease (and health) is regulated by the coordinated expression of gene cassettes or pathways. By monitoring expression patterns of the entire genome simultaneously, we can begin to identify networks of genes that work in concert to affect disease progression. Moreover, this approach can often implicate specific nexus genes that are at the center of larger networks and/or participate in multiple pathways. Additionally, we are investigating the role microRNAs, a newly discovered class of small RNA molecues, in orchestrating the activity of multiple genes during the course of disease.
Role of insulin resistance: Reduced activity of the endogenous hormone, insulin, is now recognized as a cardinal feature of type 2 diabetes and an independent risk factor for cardiovascular disease. We have investigated the effects of insulin resistance in several tissues and have recently focused our attention on adipose tissue biology and how it relates to CVD. Long known as a storage vehicle for excess calories, the fat cell is now recognized to be a factory of different products that can not only affect local activity, but can circulate in the blood as hormones and regulate many biological processes. For example, we have recently reported that the novel hormone, apelin, is produced by fat tissue and has important effects upon insulin resistance, obesity and diabetes, all of which have significant implications for cardiovascular disease.
研究兴趣
论文共 626 篇作者统计合作学者相似作者
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Alexander Schulz,Isabel N Schellinger,Sören J Backhaus, Ansgar S Adler,Torben Lange,Ruben Evertz,Johannes T Kowallick,Annett Hoffmann, Christian Matek,Philip S Tsao,Gerd Hasenfuß, Uwe Raaz,Andreas Schuster
Radiology Cardiothoracic imagingno. 4 (2024): e230344-e230344
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYno. 5 (2024): 1114-1123
Ken Suzuki,Konstantinos Hatzikotoulas,Lorraine Southam,Henry J. Taylor,Xianyong Yin,Kim M. Lorenz,Ravi Mandla,Alicia Huerta-Chagoya,Giorgio E. M. Melloni,Stavroula Kanoni,Nigel W. Rayner,Ozvan Bocher,Ana Luiza Arruda,Kyuto Sonehara,Shinichi Namba,Simon S. K. Lee,Michael H. Preuss,Lauren E. Petty,Philip Schroeder,Brett Vanderwerff,Mart Kals,Fiona Bragg,Kuang Lin,Xiuqing Guo,Weihua Zhang,Jie Yao,Young Jin Kim, Mariaelisa Graff,Fumihiko Takeuchi,Jana Nano,Amel Lamri,Masahiro Nakatochi,Sanghoon Moon,Robert A. Scott,James P. Cook,Jung-Jin Lee,Ian Pan,Daniel Taliun,Esteban J. Parra,Jin-Fang Chai,Lawrence F. Bielak,Yasuharu Tabara,Yang Hai,Gudmar Thorleifsson,Niels Grarup,Tamar Sofer,Matthias Wuttke,Chloé Sarnowski,Christian Gieger,Darryl Nousome,Stella Trompet,Soo-Heon Kwak,Jirong Long,Meng Sun,Lin Tong,Wei-Min Chen,Suraj S. Nongmaithem,Raymond Noordam,Victor J. Y. Lim,Claudia H. T. Tam,Yoonjung Yoonie Joo,Chien-Hsiun Chen,Laura M. Raffield,Bram Peter Prins,Aude Nicolas,Lisa R. Yanek,Guanjie Chen,Jennifer A. Brody,Edmond Kabagambe,Ping An,Anny H. Xiang,Hyeok Sun Choi,Brian E. Cade,Jingyi Tan,K. Alaine Broadaway,Alice Williamson,Zoha Kamali,Jinrui Cui,Manonanthini Thangam,Linda S. Adair,Adebowale Adeyemo,Carlos A. Aguilar-Salinas,Tarunveer S. Ahluwalia,Sonia S. Anand,Alain Bertoni,Jette Bork-Jensen,Ivan Brandslund,Thomas A. Buchanan,Charles F. Burant,Adam S. Butterworth,Mickaël Canouil,Juliana C. N. Chan,Li-Ching Chang,Miao-Li Chee,Ji Chen,Shyh-Huei Chen,Yuan-Tsong Chen,Zhengming Chen,Lee-Ming Chuang,Mary Cushman,John Danesh,Swapan K. Das,H. Janaka de Silva,George Dedoussis,Latchezar Dimitrov,Ayo P. Doumatey,Shufa Du,Qing Duan,Kai-Uwe Eckardt,Leslie S. Emery, Daniel S. Evans,Michele K. Evans,Krista Fischer,James S. Floyd,Ian Ford,Oscar H. Franco,Timothy M. Frayling,Barry I. Freedman,Pauline Genter,Hertzel C. Gerstein,Vilmantas Giedraitis,Clicerio González-Villalpando,Maria Elena González-Villalpando,Penny Gordon-Larsen,Myron Gross,Lindsay A. Guare,Sophie Hackinger,Liisa Hakaste,Sohee Han,Andrew T. Hattersley,Christian Herder,Momoko Horikoshi,Annie-Green Howard,Willa Hsueh,Mengna Huang,Wei Huang,Yi-Jen Hung,Mi Yeong Hwang,Chii-Min Hwu,Sahoko Ichihara,Mohammad Arfan Ikram,Martin Ingelsson,Md. Tariqul Islam,Masato Isono,Hye-Mi Jang,Farzana Jasmine,Guozhi Jiang,Jost B. Jonas,Torben Jørgensen,Frederick K. Kamanu,Fouad R. Kandeel,Anuradhani Kasturiratne,Tomohiro Katsuya,Varinderpal Kaur,Takahisa Kawaguchi,Jacob M. Keaton,Abel N. Kho,Chiea-Chuen Khor,Muhammad G. Kibriya,Duk-Hwan Kim,Florian Kronenberg,Johanna Kuusisto,Kristi Läll,Leslie A. Lange,Kyung Min Lee,Myung-Shik Lee,Nanette R. Lee,Aaron Leong,Liming Li,Yun Li,Ruifang Li-Gao,Symen Ligthart,Cecilia M. Lindgren,Allan Linneberg,Ching-Ti Liu,Jianjun Liu,Adam E. Locke,Tin Louie,Jian’an Luan,Andrea O. Luk,Xi Luo,Jun Lv,Julie A. Lynch,Valeriya Lyssenko,Shiro Maeda,Vasiliki Mamakou,Sohail Rafik Mansuri,Koichi Matsuda,Thomas Meitinger,Olle Melander,Andres Metspalu,Huan Mo,Andrew D. Morris,Filipe A. Moura,Jerry L. Nadler,Michael A. Nalls,Uma Nayak,Ioanna Ntalla,Yukinori Okada,Lorena Orozco,Sanjay R. Patel,Snehal Patil, Pei,Mark A. Pereira,Annette Peters,Fraser J. Pirie,Hannah G. Polikowsky,Bianca Porneala,Gauri Prasad,Laura J. Rasmussen-Torvik,Alexander P. Reiner,Michael Roden,Rebecca Rohde,Katheryn Roll,Charumathi Sabanayagam,Kevin Sandow,Alagu Sankareswaran,Naveed Sattar,Sebastian Schönherr,Mohammad Shahriar,Botong Shen,Jinxiu Shi,Dong Mun Shin,Nobuhiro Shojima,Jennifer A. Smith,Wing Yee So,Alena Stančáková,Valgerdur Steinthorsdottir,Adrienne M. Stilp,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Unnur Thorsteinsdottir,Brian Tomlinson,Tam C. Tran,Fuu-Jen Tsai,Jaakko Tuomilehto,Teresa Tusie-Luna,Miriam S. Udler,Adan Valladares-Salgado,Rob M. van Dam,Jan B. van Klinken,Rohit Varma,Niels Wacher-Rodarte,Eleanor Wheeler,Ananda R. Wickremasinghe,Ko Willems van Dijk,Daniel R. Witte,Chittaranjan S. Yajnik,Ken Yamamoto,Kenichi Yamamoto,Kyungheon Yoon,Canqing Yu,Jian-Min Yuan,Salim Yusuf,Matthew Zawistowski,Liang Zhang,Wei Zheng,Stavroula Kanona,Leslie J. Raffel,Michiya Igase,Eli Ipp,Susan Redline,Yoon Shin Cho,Lars Lind,Michael A. Province,Myriam Fornage,Craig L. Hanis,Erik Ingelsson,Alan B. Zonderman,Bruce M. Psaty,Ya-Xing Wang,Charles N. Rotimi,Diane M. Becker,Fumihiko Matsuda,Yongmei Liu,Mitsuhiro Yokota,Sharon L. R. Kardia,Patricia A. Peyser, James S. Pankow,James C. Engert,Amélie Bonnefond,Philippe Froguel,James G. Wilson,Wayne H. H. Sheu,Jer-Yuarn Wu,M. Geoffrey Hayes,Ronald C. W. Ma,Tien-Yin Wong,Dennis O. Mook-Kanamori,Tiinamaija Tuomi,Giriraj R. Chandak,Francis S. Collins,Dwaipayan Bharadwaj,Guillaume Paré,Michèle M. Sale,Habibul Ahsan,Ayesha A. Motala,Xiao-Ou Shu,Kyong-Soo Park,J. Wouter Jukema,Miguel Cruz,Yii-Der Ida Chen,Stephen S. Rich,Roberta McKean-Cowdin,Harald Grallert,Ching-Yu Cheng,Mohsen Ghanbari,E-Shyong Tai,Josee Dupuis,Norihiro Kato,Markku Laakso,Anna Köttgen,Woon-Puay Koh,Donald W. Bowden,Colin N. A. Palmer,Jaspal S. Kooner,Charles Kooperberg,Simin Liu,Kari E. North,Danish Saleheen,Torben Hansen,Oluf Pedersen,Nicholas J. Wareham,Juyoung Lee,Bong-Jo Kim,Iona Y. Millwood,Robin G. Walters,Kari Stefansson,Emma Ahlqvist,Mark O. Goodarzi,Karen L. Mohlke,Claudia Langenberg,Christopher A. Haiman,Ruth J. F. Loos,Jose C. Florez,Daniel J. Rader,Marylyn D. Ritchie,Sebastian Zöllner,Reedik Mägi,Nicholas A. Marston,Christian T. Ruff,David A. van Heel,Sarah Finer,Joshua C. Denny,Toshimasa Yamauchi,Takashi Kadowaki,John C. Chambers,Maggie C. Y. Ng,Xueling Sim,Jennifer E. Below,Philip S. Tsao,Kyong-Mi Chang,Mark I. McCarthy,James B. Meigs,Anubha Mahajan,Cassandra N. Spracklen,Josep M. Mercader,Michael Boehnke,Jerome I. Rotter,Marijana Vujkovic,Benjamin F. Voight,Andrew P. Morris,Eleftheria Zeggini
Markus U. Wagenhaeuser,Joscha Mulorz,Kim J. Krott, Agnes Bosbach,Tobias Feige, Yae H. Rhee,Madhumita Chatterjee, Niklas Petzold, Christopher Boeddeker,Wiebke Ibing,Irena Krueger, Ana M. Popovic, Ann Roseman,Joshua M. Spin,Philip S. Tsao,Hubert Schelzig,Margitta Elvers
CARDIOVASCULAR RESEARCHno. 4 (2024): 417-432
PLOS ONEno. 6 (2024): e0303792-e0303792
HEPATOLOGY COMMUNICATIONSno. 7 (2024)
Sai Zhang,Tobias Moll,Jasper Rubin-Sigler, Sharon Tu,Shuya Li,Enming Yuan, Menghui Liu, Afreen Butt,Calum Harvey, Sarah Gornall, Elham Alhalthli,Allan Shaw,Cleide Dos Santos Souza,Laura Ferraiuolo,Eran Hornstein,Tatyana Shelkovnikova, Charlotte H van Dijk,Ilia S Timpanaro,Kevin P Kenna,Jianyang Zeng,Philip S Tsao,Pamela J Shaw,Justin K Ichida,Johnathan Cooper-Knock,Michael P Snyder
medRxiv the preprint server for health sciences (2024)
Bryan R. Gorman,Michael Francis,Cari L. Nealon,Christopher W. Halladay,Nalvi Duro,Kyriacos Markianos,Giulio Genovese,Pirro G. Hysi,Helene Choquet,Natalie A. Afshari,Yi-Ju Li,Philip S. Tsao,J. Michael Gaziano,Adriana M. Hung,Wen-Chih Wu,Paul B. Greenberg,Saiju Pyarajan,Jonathan H. Lass,Neal S. Peachey,Sudha K. Iyengar
Katie Saxby,Frank Dudbridge,Tanmoy Roychowdhury,Derek Klarin,Greg Jones,Philip Tsao,Scott Damrauer,Matthew Bown, Christopher Nelson
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 416-416
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Xuan Wang,Molei Liu,Isabelle-Emmanuella Nogues,Tony Chen,Xin Xiong,Clara-Lea Bonzel,Harrison Zhang,Chuan Hong,Yin Xia,Kumar Dahal,Lauren Costa,Jing Cui,J. Michael Gaziano,Seoyoung C. Kim,Yuk-Lam Ho,Kelly Cho,Tianxi Cai,Katherine P. Liao,Sumitra Muralidhar,Jennifer Moser,Jennifer E. Deen,Philip S. Tsao,Elizabeth Hauser, Amy Kilbourne,Shiuh-Wen Luoh,Michael Matheny, Dave Oslin,Lori Churby,Stacey B. Whitbourne,Jessica V. Brewer, Shahpoor Shayan,Luis E. Selva,Saiju Pyarajan,Scott L. DuVall,Mary T. Brophy, Brady Stephens, Todd Connor,Themistocles L. Assimes,Adriana Hung,Henry Kranzler, Samuel Aguayo, Sunil Ahuja, Kathrina Alexander, Xiao M. Androulakis,Prakash Balasubramanian, Zuhair Ballas,Jean Beckham, Sujata Bhushan,Edward Boyko, David Cohen, Louis Dellitalia, L. Christine Faulk,Joseph Fayad, Daryl Fujii, Saib Gappy, Frank Gesek, Jennifer Greco,Michael Godschalk, Todd W. Gress, Samir Gupta, Salvador Gutierrez, John Harley, Kimberly Hammer, Mark Hamner, Robin Hurley, Pran Iruvanti, Frank Jacono, Darshana Jhala,Scott Kinlay, Jon Klein, Michael Landry, Peter Liang, Suthat Liangpunsakul, Jack Lichy, C. Scott Mahan, Ronnie Marrache,Stephen Mastorides, Elisabeth Mates,Kristin Mattocks, Paul Meyer, Jonathan Moorman,Timothy Morgan,Maureen Murdoch, James Norton, Olaoluwa Okusaga,Kris Ann Oursler, Ana Palacio,Samuel Poon, Emily Potter, Michael Rauchman, Richard Servatius, Satish Sharma, River Smith,Peruvemba Sriram, Patrick Strollo, Neeraj Tandon,Philip Tsao, Gerardo Villareal, Agnes Wallbom, Jessica Walsh, John Wells,Jeffrey Whittle,Mary Whooley, Allison E. Williams, Peter Wilson, Junzhe Xu, Shing
Scientific reportsno. 1 (2024)
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作者统计
#Papers: 630
#Citation: 36422
H-Index: 97
G-Index: 184
Sociability: 9
Diversity: 0
Activity: 6
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