基本信息
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Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and mechanics of cytoskeletal polymers using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.
Research Interests
Papers共 608 篇Author StatisticsCo-AuthorSimilar Experts
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Giulia Bergamaschi, Andreas S Biebricher,Hannes Witt, Fitzroy J Byfield, Xamanie M R Seymonson, Cornelis Storm,Paul A Janmey, Gijs J L Wuite
Cell reportsno. 10 (2024): 114852-114852
Mechanobiology in Medicinepp.100071, (2024)
Methods in enzymology (2024): 359-386
Joonho Yoon,Zhenan Liu, Mathew Alaba,Leslie A Bruggeman,Paul Janmey, Carlos Arana, Oluwatoyosi Ayenuyo,Isabela Medeiros,Viji Nair,Sean Eddy,Matthias Kretzler,Joel M Henderson, Abijit Naik,Audrey N Chang,R Tyler Miller
bioRxiv : the preprint server for biology (2024)
Journal of Biological Chemistry (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 16 (2023)
Neurologia i neurochirurgia polskano. 1 (2023): 14-25
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Encyclopedia of Cell Biologypp.225-232, (2023)
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Author Statistics
#Papers: 611
#Citation: 56835
H-Index: 110
G-Index: 228
Sociability: 7
Diversity: 0
Activity: 2
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