Fier Patrick S - Dept Chem, Univ Calif Berkeley

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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation As a Batch–Flow Process

Douglas A. L. Otte,Reed T. Larson,Embarek Alwedi,Travis Armiger,Yonggang Chen,Cheol K. Chung,James Corry,Richard Desmond,Patrick S. Fier, Robert D. Franklin,Erik D. Guetschow, Jackson R. Hall,Holst M. Halsey,Clara Hartmanshenn,Lisa Jellett,Nadine Kuhl,Francois Levesque,Jonathan P. McMullen, Pratiq A. Patel, Mellie June Paulines, Hong Ren, Vailankanni L. Rodrigues,Serge Ruccolo,Lushi Tan,David A. Thaisrivongs,Kai-Jiong Xiao

Organic Process Research & Developmentno. 5 (2024): 1402-1410

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Transition-Metal-Free C-N Cross-Coupling Enabled by a Multifunctional Reagent

Patrick S. Fier,Suhong Kim

JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 10 (2024): 6476-6480

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Dynamic Sampling in Autonomous Process Optimization

Melodie Christensen,Yuting Xu,Eugene E. Kwan,Michael J. Di Maso,Yining Ji,Mikhail Reibarkh,Alexandra C. Sun,Andy Liaw,Patrick S. Fier,Shane Grosser,Jason E. Hein

CHEMICAL SCIENCEno. 19 (2024): 7160-7169

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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib

Robert D. Franklin,Travis Armiger,Douglas A. L. Otte,Reed T. Larson,Glenn Spencer, Pratiq A. Patel, Mellie June Paulines, Jackson R. Hall,Kai-Jiong Xiao,Patrick S. Fier, Vailankanni L. Rodrigues,Erik D. Guetschow,Nadine Kuhl,Lisa Jellett,James Corry,Cheol K. Chung,David A. Thaisrivongs

Organic Process Research & Developmentno. 5 (2024): 1411-1421

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Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19

Rachel Bade,Jameson R. Bothe,Eric Sirota,Andrew P. J. Brunskill,Justin A. Newman,Yongqian Zhang,Melissa Tan,Michelle Zheng,Gilmar Brito,Marc Poirier,Patrick S. Fier,Yingju Xu, Michael D. Ward,Kevin Stone,Ivan H. Lee, Andrew J. Gmitter,Frank Bernardoni,Michael A. Zompa,Hanlin Luo,Sanjaykumar Patel, Tina Masiuk, Jeff Mora, Tong Ni,Grace A. Okoh, James Tarabokija, Jiaying Liu,Michael B. Lowinger, Tariq Mahmood

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2023)

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The Direct Conversion of Esters to Ketones Enabled by a Traceless Activating Group

Patrick S. Fier,Riley A. Roberts,Reed T. Larson

Organic letters（2023）

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A Kinase-Cgas Cascade to Synthesize a Therapeutic STING Activator

John A. McIntosh,Zhijian Liu,Brian M. Andresen,Nastaran Salehi Marzijarani,Jeffrey C. Moore,Nicholas M. Marshall,Margie Borra-Garske,Jennifer V. Obligacion,Patrick S. Fier,Feng Peng,Jacob H. Forstater,Matthew S. Winston,Chihui An,Wonsuk Chang,Jongwon Lim,Mark A. Huffman,Steven P. Miller,Fuh-Rong Tsay,Michael D. Altman,Charles A. Lesburg,Dietrich Steinhuebel,B. Wesley Trotter,Jared N. Cumming,Alan Northrup,Xiaodong Bu,Benjamin F. Mann,Mirlinda Biba,Kaori Hiraga,Grant S. Murphy,Joshua N. Kolev,Amanda Makarewicz,Weilan Pan,Iman Farasat,Rachel S. Bade,Kevin Stone,Da Duan,Oscar Alvizo,Donovan Adpressa,Erik Guetschow,Erik Hoyt,Erik L. Regalado,Steve Castro,Nelo Rivera,Joseph P. Smith,Fengqiang Wang,Alejandro Crespo,Deeptak Verma,Stephanus Axnanda,Zachary E. X. Dance,Paul N. Devine,David Tschaen,Keith A. Canada,Paul G. Bulger,Benjamin D. Sherry,Matthew D. Truppo,Rebecca T. Ruck,Louis-Charles Campeau,David Jonathan Bennett,Guy R. Humphrey,Kevin R. Campos,Matthew L. Maddess

Nature（2022）

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Biocatalytic Syntheses of Antiviral Nucleosides Islatravir and Molnupiravir

Patrick S. Fier, Megan H. Shaw

Elsevier eBooks (2022)

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Biocatalytic Syntheses of Antiviral Nucleosides Islatravir and Molnupiravir

Patrick S. Fier, Megan H. Shaw

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (2022)

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