His main research foci have been in the fields of tissue engineering and prosthetic cardiovascular implants. Pioneering tissue engineering since 1983, he developed a method of culturing the patient’s own endothelial cells on prosthetic surfaces. Today, after an international multi-centre study in the 1990s and with almost 500 patient-implants, the program is a show-case for clinical tissue engineering. Reflecting the wide impact of this aspect of his work, it has been cited almost 1500 times in the literature and he continues to give plenary talks at major conferences on the subject.