His research addresses the theoretical and experimental basis of oxygen transport and its limitations in the lungs and skeletal muscles in health and disease.

A particular focus is muscle capillary growth regulation using molecular biological approaches in integrated systemsto investigate the role of O2, microvascular hemodynamics, physical factors, nitric oxide and inflammatory mediators in transcriptional regulation of angiogenic growth factors. Of particular interest is the role of VEGF in both pulmonary and skeletal muscle structure and function.