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Perpetua Pinto-do-Ó is an Investigator at the INEB (Instituto de Engenharia Biomédica) & I3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), where she leads a research group focused on Stem Cell and Regenerative Biology. Perpetua background enables her to explore both basic and applied science from a multitude of perspectives. Shortly, after completing a degree in Biology and a three years internship in Pharmacology (Faculty of Medicine, Porto University/Department for Molecular Medicine, Karolinska Institute, Stockholm), Perpetua enrolled in the Gulbenkian PhD Program in Biology and Medicine (IGC, Oeiras, Portugal) in 1995. This was her opportunity to get in touch with Developmental Biology and Stem Cells, an area that she pursed, and in which got a PhD degree from Umeå University, Sweden (1996-2002). During this period, Perpetua was involved in the development of two cell lines, one derived from embryonic stem (ES) cells (A.K.A. HPC-7) and the other from adult bone marrow stem/progenitor cells (A.K.A. HPC-5), which proved as an in vitro immortalized source of a high-fidelity proxy for mouse and human hematopoietic stem/progenitor cells. These lines were henceforth used by several laboratories worldwide remaining up-today as a reference in the field accounting so far over 140 citations. Afterwards, she undertook a postdoctoral training at Instituto de Biologia Molecular e Celular-IBMC (2003-2006), which allowed her to develop further skills in molecular immunology and infection. By the end of 2007, she became a researcher at INEB, where she launched a Stem Cell and Regenerative Biology research line.
Along with her long-time interest on basic stem cell biology mechanisms, Perpetua got interested on understanding the role stem/progenitor cells allocated to specific tissue/organs might have on the regeneration in the adult organism. Therefore, and as a counterpart to her experience with the highly regenerative hematopoietic system, her team at INEB initially focused on the heart (a poorly regenerative/repair system) as a model in this investigation. As a result, a series of in vivo and in vitro tools were explored, implemented and newly-created thereby allowing the establishment of a new research program on Cardiovascular Biology and Repair at the Institute. Currently, and following the recent resuming of the investigation on hematopoiesis, her lab is equipped with a highly regenerative and a poorly regenerative/repair working models. Her longstanding scientific interests are comparative studies focused on “the whether and how” stem/progenitor cells keep the homeostasis and functionally restore distinct organ-systems.
Besides her activities as a researcher, Perpetua served as the President of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC) (http://spce-tc.org/) for the biennium 2016-2017, re-elected for the 2018-2019 biennium. Moreover, since 2009 she has been responsible/collaborator for teaching distinct courses on cell engineering and stem cells in regenerative therapies at the University of Porto. Perpetua is Adjunct Professor (2012-2018) and invited Associate Professor (2019-) at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto, where she coordinates the "Stem Cell Biology" course.
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HemaSphereno. S3 (2023): e70537d0-e70537d0
Frontiers in cell and developmental biology (2023): 1265005-1265005
bioRxiv : the preprint server for biology (2023)
E. Silva, I Tome, F. Vasques-Novoa, A. Silva, G. Conceicao,D. Miranda-Silva, P. Pitrez,A. Barros, A. Leite-Moreira,P. Pinto-Do-O, S. Santos, I. F. Pires,
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