基本信息
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职业迁徙
个人简介
1972Ph.D. in Organic Chemistry, Cornell University1969。B.A. in Chemistry, University of Minnesota, Duluth。
1984-presentProfessor, University of Notre Dame。1984-1986Professor, State University of New York at Stony Brook。1980-1984Associate Professor, State University of New York at Stony Brook。1974-1980Assistant Professor, Department of Chemistry, State University of New York at Stony Brook。1973-1974Postdoctoral Fellow, Harvard University。
Selected Awards
2011-2012Tage Erlander Guest Professor of the Swedish National Research Council, University of Gothenburg and University of Stockholm2010Faculty Award, University of Notre Dame2009Joyce Award for Excellence in Undergraduate Teaching2005, 2002Kaneb Teaching Award
Research Interests
Professor Helquist's research group is concerned with two broad areas: (1) the development of new methods in synthetic organic chemistry, including the preparation, structural study, and applications of new transition metal organometallic complexes as catalysts and reagents for asymmetric synthesis; and (2) the structure, synthesis, mechanism of action, and pharmaceutical development of biologically active compounds including antibiotics and antitumor agents, many of which have their origins as natural products. Often we take advantage of the interface between these two areas by applying some of our new methods, reagents, and catalysts in the synthesis of targeted natural products.
We have developed numerous synthetic methods employing iron, nickel, copper, rhodium, palladium, titanium, zirconium, magnesium, lithium, zinc, and samarium compounds as reagents or catalysts. We have employed many of these methods in the synthesis of complex natural products. Coupled with this organometallic work is the rational design of chiral transition metal catalysts through use of molecular mechanics computational techniques. Through use of this approach, we have succeeded in obtaining metal complexes that can be employed in metal-catalyzed reactions to give products with >99% enantiomeric excess.
Recent Papers
•Grigalunas, M.; Ankner, T.; Norrby, P.O.; Wiest, O.; Helquist, P. "Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions." Org. Lett. 2014, 16 (15), 3970-3973.
•Lime, E.; Lundhohn, M.D.; Forbes, A.; Wiest, O.; Helquist, P.; Norrby, P.O. "Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation." J. Chem. Theory Comput. 2014, 10 (6), 2427-2435.
•Bourbon, P.; Peng, Q.; Ferraudi, G.; Stauffacher, C.; Wiest, O.; Helquist, P. "Development of carbamate-tethered coumrarins as phototriggers for caged nicotinamide." Bioorg. Med. Chem. Lett. 2013, 23 (23), 6321-6324.
•Helquist, P.; Maxfield, F.R.; Wiech, N.L. Wiest, O. "Treatment of Niemann-Pick Type C Disease by Histone Deacetylase Inhibitors." Neurotherapeutics 2013, 10 (4), 688-697.
•Bourbon, P.; Peng, Q.; Ferraudi, G.; Stauffacher, C.; Wiest, O.; Helquist, P. "Synthesis and photochemical behavior of coumarin-caged cholesterol." Bioorg. Med. Chem. Lett. 2013, 23 (7), 2162-2165.
•Ankner, T.; Cosner, C.C.; Helquist, P. "Palladium- and Nickel-Catalyzed Alkenylation of Enolates." Chem-Eur. J. 2013, 19 (6). 1858-1871.
研究兴趣
论文共 247 篇作者统计合作学者相似作者
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JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 15 (2024): 5796-5805
crossref(2024)
Michael P Maloney,Connor W Coley,Samuel Genheden,Nessa Carson,Paul Helquist,Per-Ola Norrby,Olaf Wiest
The Journal of organic chemistryno. 9 (2023): 5239-5241
ACS CATALYSISno. 21 (2023): 14285-14299
Margo Waters,Juliane Hopf, Emma Tam, Stephanie Wallace, Jordan Chang, Zach Bennett,Hadrian Aquino,Ryan K. Roeder,Paul Helquist,M. Sharon Stack,Prakash D. Nallathamby
Pharmaceuticals (Basel, Switzerland)no. 10 (2022)
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作者统计
#Papers: 246
#Citation: 7699
H-Index: 49
G-Index: 77
Sociability: 6
Diversity: 0
Activity: 1
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