The major interest of research has been the characterization of striatal synaptic plasticity and the critical role of dopamine and glutamate in corticostriatal long-term depression (LTD) and long-term potentiation (LTP). In the last years his group has analysed the changes of these forms synaptic plasticity in experimental models of Parkinson’s disease and L-Dopa-induced dyskinesia as well as the molecular mechanisms underlying the motor alterations in these pathological conditions.