基本信息
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The human brain contains around 100 billion neurons. Their genesis, development and degeneration are all governed by underlying gene regulatory networks (GRNs). These fundamental biological processes represent a nexus where basic and translational neurobiology converge; the same processes that orchestrate normal neuronal development, maturation and death are those that malfunction in neurodevelopmental and neurodegenerative disorders. We aim to identify these networks and uncover how they vary across individuals, thereby causing errors of neurodevelopment or susceptibility to neurodegeneration. This overarching goal is as much about developing a basic understanding of how neuronal phenotype emerges from interactions among the genes of the network as it is about translating this understanding into identification of novel therapeutic targets. All of our work is guided by a credo that understanding basic biological mechanisms and identifying targets for therapeutic intervention are inextricably intertwined. To implement this vision, we work collaboratively with basic, clinical and translational neuroscientists, molecular biologists, stem cell biologists and computational biologists.
Research Interests
Papers共 200 篇Author StatisticsCo-AuthorSimilar Experts
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Alicia Gómez-Pascual,Talel Naccache,Jin Xu,Kourosh Hooshmand,Asger Wretlind,Martina Gabrielli,Marta Tiffany Lombardo,Liu Shi,Noel J. Buckley,Betty M. Tijms,Stephanie J.B. Vos,Mara ten Kate,Sebastiaan Engelborghs,Kristel Sleegers,Giovanni B. Frisoni,Anders Wallin,Alberto Lleó,Julius Popp,Pablo Martinez-Lage,Johannes Streffer
Computers in Biology and Medicineno. C (2024)
NEURO-ONCOLOGYno. 2 (2024): 309-322
Alicia Gómez-Pascual,Talel Naccache,Jin Xu,Kourosh Hooshmand,Asger Wretlind,Martina Gabrielli,Marta Tiffany Lombardo,Liu Shi,Noel J. Buckley,Betty M. Tijms,Stephanie J. B. Vos,Mara ten Kate,Sebastiaan Engelborghs,Kristel Sleegers,Giovanni B. Frisoni,Anders Wallin,Alberto Lleó,Julius Popp,Pablo Martinez-Lage,Johannes Streffer,Frederik Barkhof,Henrik Zetterberg,Pieter Jelle Visser,Simon Lovestone,Lars Bertram,Alejo J. Nevado-Holgado,Alice Gualerzi,Silvia Picciolini,Petroula Proitsi,Claudia Verderio,Juan A. Botía,Cristina Legido-Quigley
medRxiv (Cold Spring Harbor Laboratory) (2023)
Alzheimer's & dementiano. S1 (2023)
Qiang Liu,Francesca Nicholls,Helen A. Rowland,Adrià Dangla-Valls, Shuhan Li, Yi Zhang, Piotr Kalinowski,Elena Ribe, Jamie L. Ifkovits, Sanjay Kumar, Cuong Q. Nguyen,Alejo Nevado-Holgado,Noel J. Buckley,Andrey Kormilitzin
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Alzheimer's & Dementiano. S13 (2023)
Keenan A. Walker,Jingsha Chen,Liu Shi,Yunju Yang,Myriam Fornage,Linda Zhou,Pascal Schlosser,Aditya Surapaneni,Morgan E. Grams,Michael R. Duggan,Zhongsheng Peng,Gabriela T. Gomez,Adrienne Tin,Ron C. Hoogeveen,Kevin J. Sullivan,Peter Ganz,Joni V. Lindbohm,Mika Kivimaki,Alejo J. Nevado-Holgado,Noel Buckley,Rebecca F. Gottesman,Thomas H. Mosley,Eric Boerwinkle,Christie M. Ballantyne,Josef Coresh
Science Translational Medicineno. 705 (2023)
Alicia Gómez-Pascual,Talel Naccache,Jin Xu, Koroush Hooshmand,Asger Wretlind,Martina Gabrielli,Marta Tiffany Lombardo,Liu Shi,Noel J. Buckley,Betty M. Tijms,Stephanie J. B. Vos,Mara ten Kate,Sebastiaan Engelborghs,Kristel Sleegers,Giovanni B. Frisoni,Anders Wallin,Alberto Lleó,Julius Pop,Pablo Martinez-Lage,Johannes Streffer,Frederik Barkhof,Henrik Zetterberg,Pieter Jelle Visser,Simon Lovestone,Lars Bertram,Alejo J. Nevado-Holgado,Petroula Proitsi,Claudia Verderio,Juan A. Botía,Cristina Legido-Quigley
crossref(2023)
N. J. M. Birdsall,Sophie J. Bradley,David A. Brown,Noel J. Buckley,R. A. John Challiss,Arthur Christopoulos,Richard M. Eglen,Frederick J. Ehlert,Christian C. Felder,Rudolf Hammer,H. Kilbinger,Günter Lambrecht,Christopher J. Langmead, F. Mitchelson, E. Mutschler,Neil M. Nathanson,Roy D. Schwarz,David M. Thal,Andrew B. Tobin,Céline Valant,Jürgen Wess
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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Author Statistics
#Papers: 198
#Citation: 12770
H-Index: 53
G-Index: 111
Sociability: 7
Diversity: 3
Activity: 18
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