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个人简介
Dr. Cashman’s research focus is elucidating the structure and pathogenicity of proteins which misfold in neurodegeneration, starting with the prion protein (Cell 1990). He has developed novel strategies for immunotherapeutic intervention in these diseases, which are specifically directed at peptide motifs exposed by protein misfolding, but inaccessible in native structures. This notion of targeting a propagating and toxic conformation while sparing normal proteins was pioneered by his studies of prion-specific epitopes (Nat Med 2003; Nat Rev Drug Discov 2004). With Dr. Steven Plotkin of UBC Department of Physics and Astronomy, he has also identified Aβ oligomer-specific conformational epitopes as safe targets for Alzheimer’s disease immunotherapies that spare monomers and fibrils (ACS Chem Neurosci 2018; Sci Rep 2019).
Dr. Cashman’s laboratory program in ALS is focused on propagated misfolding of the proteins SOD1, TDP43, and FUS. He established that SOD1 misfolding is transmitted between SOD1 molecules, and within and between cells in a prion-like manner, providing novel targets for immunotherapeutics (PNAS 2011; PNAS 2014). His lab has also discovered that TDP43 and FUS pathology induce cross-seeding of SOD1 misfolding, which then acquires the prion-like in vivo activity to confer on SOD1 molecules in neighboring cells (Sci Rep 2016), an example of the TDP43/FUS “pathological interactome.”
Dr. Cashman’s laboratory program in ALS is focused on propagated misfolding of the proteins SOD1, TDP43, and FUS. He established that SOD1 misfolding is transmitted between SOD1 molecules, and within and between cells in a prion-like manner, providing novel targets for immunotherapeutics (PNAS 2011; PNAS 2014). His lab has also discovered that TDP43 and FUS pathology induce cross-seeding of SOD1 misfolding, which then acquires the prion-like in vivo activity to confer on SOD1 molecules in neighboring cells (Sci Rep 2016), an example of the TDP43/FUS “pathological interactome.”
研究兴趣
论文共 401 篇作者统计合作学者相似作者
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Medicine internationalno. 2 (2024): 11-11
biorxiv(2024)
Open Biologyno. 6 (2024)
Justin K. Mielke,Mikael Klingeborn,Eric P. Schultz, Erin L. Markham, Emily D. Reese,Parvez Alam,Ian R. Mackenzie,Cindy V. Ly,Byron Caughey,Neil R. Cashman, Moses J. Leavens
ACTA NEUROPATHOLOGICAno. 1 (2024)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 5 (2024)
Neil Cashman,Beibei Zhao,Catherine Cowan, Ananya Saraph,Darren Christy,Juliane Coutts,Johanne Kaplan
NEUROLOGYno. 17 (2023)
NEUROLOGYno. 17 (2023)
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作者统计
#Papers: 401
#Citation: 15673
H-Index: 59
G-Index: 117
Sociability: 7
Diversity: 3
Activity: 36
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