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个人简介
The projects in my lab focus on the structure and function of non-coding regions of prokaryotic and eukaryotic genomes. Two genetic elements particularly abdundant in these organisms are introns and retroelements. For example, ~50% of the human genome consists of spliceosomal introns and non-LTR retroelements. Both of these are considered to have evolved from a class of introns which orginated in bacteria billions of years ago called the group II introns. Group II introns share many structural and/or biochemical features with spliceosomal introns and non-LTR retroelements. Previously, I worked on determining the first crystal structure of a group II intron (figure 1). This revealed the active site of this ribozyme to contain two catalytic metal ions coordinated by a conserved RNA structural motif called domain 5. Since the group II and spliceosomal introns both share this RNA structure, spliceosomal introns should also have the same active site arrangement.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
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Elisa Posani, Pavel Janoš,Daniel Haack,Navtej Toor, Massimiliano Bonomi, Alessandra Magistrato,Giovanni Bussi
biorxiv(2024)
bioRxiv the preprint server for biology (2024)
RNAno. 9 (2023): 1437-1451
Nature structural & molecular biologyno. 1 (2023): 179-189
Journal of Structural Biology X (2022): 100062
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作者统计
#Papers: 31
#Citation: 1761
H-Index: 15
G-Index: 22
Sociability: 4
Diversity: 3
Activity: 10
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