Nathan Bays

Dept Early Dev & Discovery Sci Merck & Co Inc

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论文共 15 篇作者统计合作学者相似作者

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The Discovery of 3-((4-chloro-3-methoxyphenyl)amino)-1-((3r,4s)-4-cyanotetrahydro-2h-pyran-3-yl)-1h-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties

Tony Siu,Jason Brubaker,Peter Fuller,Luis Torres,Hongbo Zeng,Joshua Close,Dawn M Mampreian,Feng Shi,Duan Liu,Xavier Fradera,Kevin Johnson,Nathan Bays,Elma Kadic,Fang He,Peter Goldenblatt,Lynsey Shaffer,Sangita B Patel,Charles A Lesburg,Carla Alpert,Lauren Dorosh,Sujal V Deshmukh,Hongshi Yu,Joel Klappenbach,Fiona Elwood,Christopher J Dinsmore,Rafael Fernandez,Lily Moy,Jonathan R Young

Journal of medicinal chemistry（2017）

引用11浏览0WOS引用

Bruton'S Tyrosine Kinase (Btk) Program: Quick Systematic Sar Development Utilizing Parallel Synthesis

Younong Yu,Rajan Anand,Deyou Sha,Henry Vaccaro,Milana Maletic,Rob Mazzola,Zhi-Cai Shi, Mo Abdul-Basit Alhassan,Sobhana Boga,Joseph Duffy,Xiaolei Gao,Deodial Guiadeen,Joseph Kelly,Arto Krikorian,Jian Liu,Kevin Maloney,Oleg Selytin,James Wang,Jiayi Xu,Wensheng Yu,Michael Altman,Brian Andresen,Yuan Liu,Michelle Martinez,Tony Siu,Shilan Liu,Chundao Yang,Hao Wu,Jiaqiang Cai, Ying-Duo Gao, Thierry Fischmann,Jeremy Presland,My Mansueto,Zangwei Xu,Erica Leccese,Jie Zhang-Hoover,Ian Knemeyer,Charles Garlisi,Nathan Bays,Peter Stivers,Philip Brandish,Alexandra Hicks,Ronald Kim,Joseph Kozlowski

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2017）

引用0浏览0引用

Discovery of novel BTK inhibitors with carboxylic acids

Xiaolei Gao,James Wang,Jian Liu,Deodial Guiadeen,Arto Krikorian,Sobhana Babu Boga,Abdul-Basit Alhassan,Oleg Selyutin,Wensheng Yu,Younong Yu,Rajan Anand,Shilan Liu,Chundao Yang,Hao Wu,Jiaqiang Cai,Alan Cooper,Hugh Zhu,Kevin Maloney, Ying-Duo Gao,Thierry O Fischmann,Jeremy Presland,My Mansueto,Zangwei Xu,Erica Leccese,Jie Zhang-Hoover,Ian Knemeyer,Charles G Garlisi,Nathan Bays,Peter Stivers,Philip E Brandish,Alexandra Hicks,Ronald Kim, Joeseph A Kozlowski

Bioorganic & Medicinal Chemistry Letters（2017）

引用16浏览0WOS引用

Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Sobhana Babu Boga,Abdul-Basit Alhassan,Jian Liu,Deodial Guiadeen,Arto Krikorian,Xiaolei Gao,James Wang,Younong Yu,Rajan Anand,Shilan Liu,Chundao Yang,Hao Wu,Jiaqiang Cai,Hugh Zhu,Jagdish Desai,Kevin Maloney, Ying-Duo Gao, Thierry O Fischmann,Jeremy Presland,My Mansueto,Zangwei Xu,Erica Leccese,Ian Knemeyer,Charles G Garlisi,Nathan Bays,Peter Stivers,Philip E Brandish,Alexandra Hicks,Alan Cooper,Ronald M Kim,Joseph A Kozlowski

Bioorganic & Medicinal Chemistry Letters（2017）

引用11浏览0WOS引用

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Fiona Elwood,David J. Witter,Jennifer Piesvaux,Brian Kraybill,Nathan Bays,Carla Alpert,Peter Goldenblatt,Yujie Qu,Irena Ivanovska,Hyun-Hee Lee,Chi-Sung Chiu, Hao Tang,Mark E. Scott,Sujal V. Deshmukh,Mark Zielstorff,Alan Byford,Kalyan Chakravarthy,Lauren Dorosh, Alexey Rivkin,Joel Klappenbach,Bo-Sheng Pan,Ilona Kariv,Christopher Dinsmore,Deborah Slipetz,Peter J. Dandliker

The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experi...（2017）

引用21浏览0WOS引用

ffi cient and E ffi cacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties

T. Siu,Jason D. Brubaker,P. Fuller,Luis E. Torres,Hongbo Zeng,Joshua Close,Dawn M. Mampreian,F. Shi,Duan Liu,X. Fradera, Kevin Johnson,Nathan W Bays,Elma Kadić, Fangfei He,P. Goldenblatt, Lynsey Sha, Er,Sangita Patel,C. Lesburg,Carla Alpert,Lauren A. Dorosh,S. Deshmukh,Hongshi Yu,J. Klappenbach,F. Elwood,C. Dinsmore,Rafael Fernandez,L. Moy,Jonathan R. Young

semanticscholar（2017）

引用0浏览0引用

Optimization Of Btk Inhibitors To Mitigate Kinase Selectivity, Pk And Off Target Shortcomings

Deodial Guiadeen,Jian Liu,Arto Krikorian,Xiaolei Gao,James Wang,Sobhana Boga,Abdul-Basit Alhassan,Jiayi Xu,Joseph Kelly,Rajan Anand,Younong Yu,Oleg Selyutin,Wensheng Yu,Shilan Liu,Chundao Yang,Hao Wu,Jiaqiang Cai,Kevin Maloney, Viktor Honak, Ying-Duo Gao,Sriram Tyagarajan, Thierry Fischmann,Jeremy Presland,My Mansueto,Zangwei Xu,Erica Leccese,Jie Zhang-Hoover,Ian Knemeyer,Nathan Bays,Peter Stivers,Philip Brandish, Alexander Hicks,Ronald Kim,Joseph Kozlowski

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2016）

引用0浏览0引用

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Jian Liu, D Guiadeen,Arto D Krikorian,Xiaolei Gao,James Wang,Sobhana Babu Boga,Abdulbasit Alhassan,Younong Yu,Henry A Vaccaro,Shilan Liu,Chundao Yang,Hao Wu,Alan B Cooper,Jos De Man,Allard Kaptein,Kevin Maloney,Viktor Hornak, Yingduo Gao, Thierry O Fischmann,Hans C A Raaijmakers,Diep Vupham,Jeremy Presland,My Mansueto,Zangwei Xu,Erica Leccese,Jie Zhanghoover,Ian Knemeyer,Charles G Garlisi,Nathan Bays,Peter Stivers,Philip E Brandish,Alexandra Hicks,Ronald Kim,Joseph A Kozlowski

ACS medicinal chemistry letters（2016）

引用37浏览0WOS引用

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Christian Fischer,Susan L Zultanski,Hua Zhou,Joey L Methot,Sanjiv Shah,Ikuo Hayashi,Bethany Hughes,Christopher M Moxham,Nathan Bays,Nadya Smotrov,Armetta D Hill, B Pan,Zhenhua Wu,Lily Y Moy,Flobert Tanga,Candia M Kenific,Jonathan C Cruz, D Walker,Melanie Bouthillette,George N Nikov,Sujal V Deshmukh,Valentina V Jeliazkovamecheva,Damaris Diaz,Maria S Michener,Jacquelynn J Cook,Benito Munoz,Mark S Shearman

Bioorganic & Medicinal Chemistry Letters（2015）

引用13浏览0WOS引用

Triazoloamides As Potent Γ-Secretase Modulators with Reduced Herg Liability

Christian Fischer,Susan L. Zultanski,Hua Zhou,Joey L. Methot,Sanjiv Shah,Hugh Nuthall,Bethany L. Hughes,Nadja Smotrov,Armetta Hill,Alexander A. Szewczak,Christopher M. Moxham,Nathan Bays,Richard E. Middleton,Benito Munoz,Mark S. Shearman

Bioorganic &amp Medicinal Chemistry Letters（2012）

引用17浏览0引用

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作者统计

#Papers: 15

#Citation: 229

H-Index: 10

G-Index: 11

Sociability: 5

Diversity: 2

Activity: 0

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