Dr. Ueno has a strong background in translational breast cancer research in cancer biology, immuno-oncology, and molecular therapeutics. He is one of the leaders in conducting clinical research and early-phase clinical trials related to aggressive breast cancer and has led more than 50 clinical trials. Dr. Ueno has extensive experience in conducting both targeted therapy-related and immunotherapy-related clinical trials in phase I and II settings. He expanded his research to include several protein enzymes, including Mitogen-activated protein, Extracellular signal-regulated kinase (MAPK/ERK), and C-JUN N-terminal kinase, among other protein enzymes to determine their role in breast cancer progression and their applications in the development of targeted therapy and immunotherapy. Over the past 10 years, Dr. Ueno has successfully managed projects in breast cancer biology related to triple-negative breast cancer (TNBC), inflammatory breast cancer (IBC), and the tumor microenvironment.
Dr. Ueno is passionate about developing innovative therapies for advanced breast cancer. He started his career developing gene therapy for breast cancer and prepared for an Investigational New Drug application to conduct a study of gene therapies for metastatic breast cancer. His focus has been on novel combination therapy, IBC, and TNBC. Currently, Dr. Ueno is the lead national PI on antibody-conjugate drugs-related clinical trials.