Nicole Juffermans’ work is focused on improving the condition of ICU patients and the efficacy of medical interventions. In her capacity as principal investigator at the Academic Medical Center, she heads a research line that investigates the efficacy of blood transfusions and associated blood clotting, anaemia, infections and inflammation. This research is being conducted within a European framework and in partnership with various departments at the AMC and Sanquin Blood Supply. In addition, Juffermans focuses on regulating hyperinflammation during episodes of critical illness by slowing the metabolism in a controlled manner. This research project is also taking place within a European framework and involves various disciplines. Besides her research work, Juffermans is involved in the department’s education programme and provides education and training to trainee specialists, emergency physicians and ICU nursing staff.