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个人简介
For 42 years, Dr. Levine has conducted Phase 1, 2, 3, and 4 clinical trials to evaluate the safety, immunogenicity, and efficacy of a wide array of vaccines; served as a clinician in vaccine testing for both adults and children; designed and supervised domestic and international epidemiologic studies; overseen research activities in the laboratory; and supervised development of diagnostic assays for use in developing countries and subsequent testing in field trials. His laboratory research has focused on the construction and characterization of attenuated strains of Salmonella Typhi, S. Paratyphi A, non-typhoidal Salmonella serovars, and Shigella to serve as live oral vaccines and as live vectors for the expression of foreign antigens. Multiple constructs have progressed from animal models to human trials.
Dr. Levine has designed and supervised large-scale, randomized, controlled field trials that investigated the efficacy of live oral typhoid vaccine Ty21a, which led to its licensure by the US Food and Drug Administration (FDA). Post-licensure work with Haemophilus influenzae type b conjugate vaccine led to early introductions into the routine infant immunization schedule in Chile (1996) and Mali, West Africa (2005). After years of challenge trials and an effective clinical trial, the single-dose oral cholera vaccine, Vaxchora, was approved for licensure by the FDA in 2016.
Dr. Levine has designed and supervised large-scale, randomized, controlled field trials that investigated the efficacy of live oral typhoid vaccine Ty21a, which led to its licensure by the US Food and Drug Administration (FDA). Post-licensure work with Haemophilus influenzae type b conjugate vaccine led to early introductions into the routine infant immunization schedule in Chile (1996) and Mali, West Africa (2005). After years of challenge trials and an effective clinical trial, the single-dose oral cholera vaccine, Vaxchora, was approved for licensure by the FDA in 2016.
研究兴趣
论文共 902 篇作者统计合作学者相似作者
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Modupeh Betts,Michel Dione,Usman Nurudeen Ikumapayi,Madikay Senghore,Modou Lamin, Ebenezer Foster-Nyarko, James Jaffali,Sandra Panchalingam,James P Nataro,Karen L Kotloff,Myron M Levine,Debasish Saha,Jahangir M Hossain,Brenda Kwambana-Adams,Martin Antonio
biorxiv(2024)
Frontiers in Immunology (2024)
Danielle J. Ingle,Jane J. Hawkey,Martin Hunt,Zamin Iqbal,Jacqueline Keane,Ayorinde Oluwatobiloba Afolayan,Niyaz Ahmed,Saadia Andleeb,Philip M Ashton,Isaac I. Bogoch,Megan E. Carey, Marie Anne Chattaway,John A Crump,Paula Diaz Guevara,Benjamin Howden,Hidemasa Izumiya,Jobin John Jacob,Louise M Judd, Arti Kapil, Karen H Keddy, Justin Kim,Myron M Levine,Masatomo Morita, Satheesh Nair,Sophie Octavia,Iruka N Okeke, Precious Osadebamwen,Sadia Isfat Ara Rahman,Assaf Rokney,David Rasko,Varun Shamanna,Michael J. Sikorski,Anthony M Smith, Gabriel T Sunmonu,Kaitlin A Tagg,Ryan R Wick,Zoe A Dyson, Kat Holt, Global Typhoid Genomics Consortium
biorxiv(2024)
JOURNAL OF INFECTIOUS DISEASESno. 2 (2024): e254-e267
Jordan Cates,Helen Powell,James Platts-Mills,Dilruba Nasrin,Sandra Panchalingam,Samba O. Sow,Awa Traore,Dipika Sur,Thandavarayan Ramamurthy,Anita K. M. Zaidi,Furqan Kabir,Abu S. G. Faruque,Dilruba Ahmed,Robert F. Breiman,Richard Omore,John Benjamin Ochieng,M. Jahangir Hossain,Martin Antonio,Inacio Mandomando,Delfino Vubil,James P. Nataro,Myron M. Levine,Umesh D. Parashar,Karen L. Kotloff,Jacqueline E. Tate
The Journal of infectious diseasesno. 5 (2024): 1157-1166
FRONTIERS IN IMMUNOLOGY (2024)
MICROBIAL GENOMICSno. 3 (2024)
Frontiers in Immunology (2024)
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#Papers: 895
#Citation: 60086
H-Index: 122
G-Index: 212
Sociability: 8
Diversity: 4
Activity: 66
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