J.J. (Jan) Molenaar

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Bio

The Molenaar group aims to develop new treatment options for pediatric cancer. We do this by connecting basic biological research to immuno- as well as targeted therapies. New therapeutic options are eventually applied in clincal trials through our precision medicine program. Our translational work has a strong focus on neuroblastoma tumors.

Research Interests

Papers共 224 篇Author StatisticsCo-AuthorSimilar Experts

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Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

Marta Barisa,Elisa Zappa, Henrike Muller, Rivani Shah,Juliane Buhl,Benjamin Draper,Courtney Himsworth,Chantelle Bowers, Sophie Munnings-Tomes, Marilena Nicolaidou, Sonia Morlando, Katie Birley,Clara Leboreiro-Babe,Alice Vitali,Laura Privitera, Kyle O’Sullivan, Ailsa Greppi,Magdalena Buschhaus,Mario Barrera Román,Sam de Blank,Femke van den Ham, Brenna R. van ‘t Veld,Gabrielle Ferry,Laura K. Donovan,Louis Chesler,Jan Molenaar,Jarno Drost,Anne Rios,Kerry Chester,Judith Wienke,John Anderson

biorxiv（2024）

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ITCC-P4, a Preclinical Proof-of-concept Drug Testing Platform As a Tool for Pharmacological Screening in Pediatric Tumor Models

Emilie Indersie, Sophie Branchereau,Brice Fresneau, Christophe Chardot,Didier Surdez, Alexandra Saint-Charles, Maria Eugenia Marques da Costa, Angel M. Carcaboso,Katia Scotlandi,Massimo Moro,Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin,Simon Bomken,Louis Chesler,Chris Jones,Beat Schafer,Marco Wachtel,Johannes Gojo,Walter Berger,Christina Guttke,Maureen Hattersley,Frederic Colland, Ashley Strougo,Dennis Gurgen,Jens Hoffmann,Julia Schueler, Pablo M. Aviles,Maria Jose Guillen,Aniello Federico,Apurva Gopisetty, Justyna Anna Wierzbinska, Andreas Schlicker,Sara Colombetti,Olaf Heidenreich,Fatima Iradier, Nicole Huebener,Natalie Jager, Jan Koster,Marcel Kool,Gudrun Schleiermacher,Jan J. Molenaar,Birgit Geoerger,David J. Shields, Hubert N. Caron,Louis F. Stancato,Stefan M. Pfister,Gilles Vassal, Eva-Maria Rief,Olivier Deas

CANCER RESEARCHno. 6 (2024)

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Whole Genome Sequencing Can Reproduce All Standard-of-care Diagnostics for Childhood Cancer: Results from Two National Systems

Jonathan Kennedy,Sarah M. Leiter,Angus Hodder, Sheng-Yuan Kan,Jack Bartram,Giuseppe Barone,Michael Gattens,Matthew J. Murray,Sam Behjati,Patrick Tarpey,Matthew Cullen, Antony Ceraulo,Karin Langenberg,Jan Molenaar,Sandra Wessman,Frida Abel,Gustaf Ljungman,Geraldine Giraud, Hakon Anderson Blomstrand, Zdenek Rohan,Anna Staffas,Christina Orsmark-Pietras,Tatjana Pandzic,Irina Golovleva,Linda Fogelstrand,Jonas Abrahamsson,Ulrika Noren-Nystrom,Josefine Palle,Thoas Fioretos,Lucia Cavelier Franco,Gisela Barbany,Nadege Corradini, Gudrun Schleirmacher,Richard Rosenquist, David Gisselsson,Aditi Vedi

CANCER RESEARCHno. 17 (2024)

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Integrative Analysis of Neuroblastoma by Single-Cell RNA Sequencing Identifies the NECTIN2-TIGIT Axis As a Target for Immunotherapy

CANCER CELLno. 2 (2024)

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Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

Josephine G. M. Strijker,Guillem Pascual-Pasto, Yannine J. Kalmeijer, Elisavet Kalaitsidou,Chunlong Zhao,Brendan McIntyre, Stephanie Matlaga,Lindy L. Visser,Marta Barisa,Courtney Himsworth, Rivani Shah, Henrike Muller,Linda G. Schild,Peter G. Hains,Qing Zhong,Roger Reddel,Phillip J. Robinson,Xavier Catena,María S. Soengas,Thanasis Margaritis,Frank J. Dekker,John Anderson,Jan J. Molenaar,Kristopher R. Bosse,Wei Wu,Judith Wienke

biorxiv（2024）

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Metastatic Tumor Cells in Bone Marrow Differ from Paired Neuroblastoma Tumor and Contain Subsets with Therapy-Resistant Characteristics

Caroline Hochheuser, Arjan Boltjes,Kaylee M. Keller,Simon Tol, Marieke van de Mheen, Carolina Pita Barros, Zeinab van Gestel-Fadaie, André B. P. van Kuilenburg,Sander van Hooff,Carlijn Voermans,Jan J. Molenaar,Godelieve A. M. Tytgat,Ilse Timmerman

biorxiv（2024）

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Next Generation Pediatric Precision Oncology: Functional Profiling of Patient-Derived Viable Tumor Material to Link Genotype and Phenotype

Eleonora J. Looze, Jie Mao,Heike Peterziel, Arjan Boltjes,Bianca Koopmans,Jan Koster,Marcel Kool,Max M. Van Noesel,Olaf Witt,Jan J. Molenaar,Ina Oehme,M. Emmy M. Dolman,Karin P. S. Langenberg

CANCER RESEARCHno. 17 (2024)

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Abstract 5469: ITCC-P4, a Preclinical Proof-of-concept Drug Testing Platform As a Tool for Pharmacological Screening in Pediatric Tumor Models

Cancer Researchno. 6_Supplement (2024): 5469-5469

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A Multispectral 3D Live Organoid Imaging Platform to Screen Probes for Fluorescence Guided Surgery

Bernadette Jeremiasse, Ravian L. van Ineveld, Veerle Bok,Michiel Kleinnijenhuis,Sam de Blank,Maria Alieva,Hannah R. Johnson,Esmee J. van Vliet,Amber L. Zeeman,Lianne M. Wellens, Gerard Llibre-Palomar,Mario Barrera Roman,Alessia Di Maggio,Johanna F. Dekkers, Sabrina Oliveira,Alexander L. Vahrmeijer,Jan J. Molenaar,Marc H. W. A. Wijnen,Alida F. W. van der Steeg,Ellen J. Wehrens,Anne C. Rios

EMBO molecular medicine（2024）

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P12.09 Expanded T Cell Clones in Neuroblastoma Persist Throughout Chemotherapy and Display a Druggable Dysfunctional Profile

J Wienke,JJ Molenaar, E Zappa, A Boltjes, N Hiddink Verberne

Poster presentations (2024)

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Papers共 224 篇Author StatisticsCo-AuthorSimilar Experts