Minjie Zhang - Boston Biomedical, Inc.

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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That is Synthetically Lethal with MTAP-Deleted Cancers

Kevin M. Cottrell,Kimberly J. Briggs,Douglas A. Whittington,Haris Jahic,Janid A. Ali,Charles B. Davis,Shanzhong Gong,Deepali Gotur,Lina Gu,Patrick McCarren,Matthew R. Tonini,Alice Tsai,Erik W. Wilker, Hongling Yuan,Minjie Zhang,Wenhai Zhang,Alan Huang,John P. Maxwell

JOURNAL OF MEDICINAL CHEMISTRYno. 8 (2024): 6064-6080

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Abstract 4631: Evaluation of the impact of homozygous MTAP truncations on the activity and selectivity of MTA-cooperative PRMT5 inhibitors

Matthew R. Tonini, Andre A. Mignault,Douglas A. Whittington, Steven A. Lombardo,Binzhang Shen,Hannah Stowe, Satoshi Yoda,Shangtao Liu,Minjie Zhang,Kevin M. Cottrell,Samuel R. Meier, Heidi Rego,Jennifer Morawiak,Ellen Hooper,Yi Yu,Heather DiBenedetto,Adam S. Crystal, Teng,Kimberly Briggs

Cancer Researchno. 6_Supplement (2024): 4631-4631

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Abstract 3916: TNG260, a Small Molecule CoREST Inhibitor, Sensitizes STK11-mutant NSCLC to Anti-Pd1 Immunotherapy

Ayushi Patel,Soumyadip Sahu,Ke Geng,Salman Punekar,Janaye Stephens,Jiehui Deng,Ting Chen,Leanne Ahronian,Minjie Zhang,Jannik Andersen,Brian Haines,Kwok-Kin Wong

Cancer Researchno. 6_Supplement (2024): 3916-3916

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Abstract 3242: TNG917 is a clinical-grade, potent and selective inhibitor of EHMT1/2 for the treatment of immune cold tumors

Alvin Lu,Brian Haines, Ji Lei,Wenhai Zhang,Minjie Zhang,Douglas A. Whittington, Maria Lucia Ferdinez,Yi Yu,Samuel R. Meier,Ashley Choi,Alborz Bejnood,Madhavi Bandi,Katherine Lazarides,Xuewen Pan,Lina Gu,Alice W. Tsai,Sirimas Sudsakorn,Colin Liang,Jon Come, Brett Williams,Scott Throner,Joseph Vacca,John P. Maxwell, Jannik N. Anderson,Alan Huang,Chengyin Min,Yingnan P. Chen

Cancer Researchno. 6_Supplement (2024): 3242-3242

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TNG462 is a Potential Best-in-class MTA-cooperative PRMT5 Inhibitor for the Treatment of Peripheral MTAP-deleted Solid Tumors

Kimberly J. Briggs,Alice Tsai,Minjie Zhang,Matthew R. Tonini,Brian Haines,Alan Huang,Kevin M. Cottrell

CANCER RESEARCH（2023）

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870 CoREST Inhibition by TNG260 Increases Expression of Immunomodulatory Genes in STK11-mutant Cancer and Sensitizes to Immune Checkpoint Blockade

Alan Huang,Andre Mignault,Minjie Zhang,Yi Yu,Leanne Ahronian, Xinyuan Wu,Chengyin Min,Alborz Bejnood,Nikitha Das,Preksha Shahagadkar,Alice W Tsai,Lauren Flynn,Heather DiBenedetto,Adam S Crystal

Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)

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Abstract ND12: TNG260: A novel, orally active, CoREST-selective deacetylase inhibitor for the treatment of STK11-mutant cancers

Leanne G. Ahronian,Minjie Zhang,Chengyin Min,Alice Tsai,Jacques Ermolieff,Patrick McCarren, Margaret Wyman, David Guerin, Ye Wang,Alborz Bejnood, Kenjie Amemiya,Brian McMillan,Nikitha Das,Preksha Shahagadkar, Brian Doyon,Andre Mignault,Colin Liang, Vassil I. Elitzin,Samuel R. Meier,Ashley H. Choi, Yu Chen,John P. Maxwell,Brian B. Haines,Jannik N. Andersen,Heather DiBenedetto,Aaron Weitzman,Alan Huang, Xinyuan Wu

Cancer Researchno. 7_Supplement (2023): ND12-ND12

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Abstract 3452: TNG908, a Brain-Penetrant MTA-cooperative PRMT5 Inhibitor, is Efficacious in Preclinical Glioblastoma Models

Minjie Zhang,Alice Tsai,Kevin M. Cottrell,Brian B. Haines,Erik Wilker,Heather DiBenedetto, Ron Weitzman,Alan Huang,Charles B. Davis,John P. Maxwell,Kimberly J. Briggs

Cancer Researchno. 7_Supplement (2023): 3452-3452

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Abstract 4968: Characterization of the Clinical Development Candidate TNG348 As a Potent and Selective Inhibitor of USP1 for the Treatment of BRCA1/2mut Cancers

Cancer researchno. 7_Supplement (2023): 4968-4968

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