基本信息
浏览量:12
职业迁徙
个人简介
The pervasive influence of the immune system on human health and disease underscores the importance of mechanistic understanding of immune regulation under pathophysiological conditions. Modern immunology is built on the foundation of clonal selection and pattern recognition theories that emphasize innate and adaptive immune recognition in controlling immune responses. Despite the compelling power of these theories to explain immune responses to infection, they are inadequate in addressing how autoreactive lymphocytes are tolerized, the ability of naïve and memory lymphocytes to be maintained in the absence of cognate antigens, and the mechanisms by which immune responses are regulated in the context of non-classical scenarios of antigen exposure such as cancer. We have postulated that regulatory mechanisms, established by co-opting evolutionarily ancient cell signaling modules, work in concert with innate and adaptive sensing mechanisms to ensure well-ordered immune activities. To this end, studies from my laboratory have led to the elucidation of critical roles for TGF-β, Notch, Foxo and the nutrient-sensing pathways in the control of T lymphocyte development, homeostasis, tolerance, and memory, as well as innate and adaptive immune responses to cancer. A major current focus in the lab is to study how these conserved metazoan cell signaling modules are rewired in the immune system using diverse immunological, genetic, biochemical, and genomic approaches, and to exploit these regulatory pathways for disease therapy.
研究兴趣
论文共 215 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Annual review of immunologyno. 1 (2024): 647-677
Journal of cellular and molecular medicineno. 6 (2024): e18186-e18186
bioRxiv : the preprint server for biology (2024)
Immunological reviewsno. 1 (2024): 150-163
Cell Chemical Biologyno. 5 (2024): 830-832
Daisy A Hoagland,Patricia Rodríguez-Morales,Alexander O Mann,Shuang Yu, Alicia Lai, Alan Baez Vazquez,Scott D Pope,Jaechul Lim,Shun Li,Xian Zhang,Ming O Li,Ruslan Medzhitov,Ruth A Franklin
bioRxiv : the preprint server for biology (2023)
STAR PROTOCOLSno. 2 (2023)
Phillip M. Rappold,Lynda Vuong,Josef Leibold,Nicholas H. Chakiryan,Michael Curry,Fengshen Kuo,Erich Sabio,Hui Jiang,Briana G. Nixon,Ming Liu,Anders Berglund,Andrew W. Silagy,Eduardo A. Mascareno,Mahdi Golkaram,Mahtab Marker,Albert Reising,Alexander Savchenko,John M. Millholland,Ying-Bei Chen,Paul Russo,Jonathan Coleman,Ed Reznik,Brandon J. Manley,Irina Ostrovnaya,Vladimir Makarov,Renzo G. DiNatale,Kyle A. Blum, Xiaoye Ma,Diego Chowell,Ming O. Li,David B. Solit,Scott W. Lowe,Timothy A. Chan,Robert J. Motzer,Martin H. Voss,A. Ari Hakimi
openalex(2023)
A. Ari Hakimi,Martin H. Voss,Fengshen Kuo, Alejandro Sánchez,Ming Liu,Briana G. Nixon,Lynda Vuong,Irina Ostrovnaya,Ying-Bei Chen,Victor E. Reuter,Nadeem Riaz, Yuan Chao,Parul Patel,Mahtab Marker,Albert Reising,Ming O. Li, Turcan,Robert J. Motzer
openalex(2023)
加载更多
作者统计
#Papers: 213
#Citation: 23908
H-Index: 66
G-Index: 154
Sociability: 7
Diversity: 0
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn