My research focuses on understanding both the causes and consequences of molecular variation in the human brain and the role this plays in dementia and neuropsychiatric disorders. My group is interested in the dynamic genomic processes occurring in the human brain during development and aging, exploring interactions between the epigenome, environment and DNA sequence variation. Using cutting-edge genomics methods, we aim to undertake an integrated genetic-epigenetic approach to disease, incorporating genetic, transcriptional and epigenomic variation. We led the first large-scale epigenomic studies of Alzheimer’s disease, and are currently investigating genomic changes in individual brain cells.