Much of my statistical research has been in the area of order-restricted inference, specifically with regard to developing novel approaches to hypothesis testing problems involving order-constrained parameters. This methodology is useful in many applications, including dose-response studies and clinical trials with multiple endpoints. I am also interested in problems of inference concerning receiver operating characteristic (ROC) curves and surfaces, including the problem of correcting verification bias that sometimes arises in studies of the performance of diagnostic tests. Other areas of interest include methods for combining p-values, reliability of measurement, meta-analysis, missing data problems, and clinical trials methodology.

I hold a joint appointment with the Department of Neurology and much of my collaborative work stems from this relationship. I have been a member of several national and international collaborative groups conducting basic and clinical research in Parkinson’s disease, Huntington’s disease, Tourette’s syndrome, epilepsy, various muscular dystrophies and other muscle diseases, HIV-associated dementia, multiple sclerosis, idiopathic intracranial hypertension, and pain.

I have served on the editorial board for the journal Movement Disorders since 2010 and as an Editor for the journal International Statistical Review since 2022. I was Associate Editor for the journal Neurology from 1997-2003 and an Editor for Chance magazine from 2014-2019. I am a Fellow of the American Statistical Association, an Elected Member of the International Statistical Institute, and a member of the Biometric Society, the Institute of Mathematical Statistics, and the Society for Clinical Trials.