Research Interests Targeting Cell Signaling for Cancer Therapy. Research Description Cells continually make decisions about their fate: growth, death or differentiation. These decisions frequently are determined by signal transduction cascades of small GTP-binding proteins and protein kinases, which are activated in response to extracellular signals. Our laboratory utilizes tools of cell biology, protein chemistry and molecular biology to understand how signal transduction controls cell growth and apoptosis, how these controls are altered in cancer, and how this information can be used to improve cancer treatment.