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职业迁徙
个人简介
Our research focuses on cellular and molecular mechanisms of frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS), two related neurodegenerative disorders. We use a combination of cell biology, proteomic, and functional genomic approaches in iPSC neuron models of ALS/FTD, with a long-term goal of understanding how disease-associated familial mutations lead to neurodegeneration. Our group has made several major contributions to the field over the past several years: 1) New tools that enable large-scale production of human iPSC-derived neurons and genome-wide CRISPRi screens, and conception and management of a large-scale genome engineering iPSC initiative (iNDI). 2) Discovery of a new mechanism of axonal RNA transport in neurons that involves lysosomal hitchhiking, a process that goes awry in familial ALS. 3) Characterization of dysregulated splicing in ALS/FTD due to mislocalization of TDP-43, uncovering novel disease-relevant splicing targets and potential biomarkers. 4) Discovery of widespread DNA break/repair events at neuronal enhancers that are likely necessary for epigenetic regulation. Each of these efforts have been highly collaborative in nature, involving multiple teams from independent institutions. Please visit https://research.ninds.nih.gov/ward-lab/publications for a more complete list of recent publications and team collaborations.
研究兴趣
论文共 474 篇作者统计合作学者相似作者
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Nature Neuroscience (2024)
Femke M Feringa, Sascha J Koppes-den Hertog, Lian Wang,Rico J.E. Derks, Iris Kruijff,Lena Erlebach, Jorin Heijneman,Ricardo Miramontes,Nadine Pömpner,Niek Blomberg,Damien Olivier-Jimenez, Lill Eva Johanson, Alexander J. Cammack,Ashling Giblin,Christina E Toomey,Indigo V.L. Rose,Hebao Yuan,Michael E. Ward,Adrian Isaacs,Martin Kampmann,Deborah Kronenberg-Versteeg,Tammaryn Lashley, Leslie M. Thompson,Alessandro Ori,Yassene Mohammed,Martin Giera,Rik H.N. van der Kant
biorxiv(2024)
Jordan D. Marks,Virginia Estades Ayuso,Yari Carlomagno,Mei Yue,Tiffany W. Todd, Ying Hao,Ziyi Li,Zachary T. McEachin,Anantharaman Shantaraman,Duc M. Duong,Lillian M. Daughrity,Karen Jansen-West,Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano,Michael DeTure, Bailey Rawlinson,Monica Castanedes Casey,Meredith T. Lilley, Megan H. Donahue, Vidhya Maheswari Jawahar,Bradley F. Boeve,Ronald C. Petersen,David S. Knopman,Bjoern Oskarsson,Neill R. Graff-Radford,Zbigniew K. Wszolek,Dennis W. Dickson,Keith A. Josephs,Yue A. Qi,Nicholas T. Seyfried,Michael E. Ward,Yong-Jie Zhang,Mercedes Prudencio,Leonard Petrucelli,Casey N. Cook
SCIENCE TRANSLATIONAL MEDICINEno. 730 (2024)
Sam Bryce-Smith,Anna-Leigh Brown,Puja R. Mehta,Francesca Mattedi,Alla Mikheenko, Simone Barattucci,Matteo Zanovello, Dario Dattilo, Matthew Yome,Sarah E. Hill,Yue A. Qi,Oscar G. Wilkins, Kai Sun, Eugeni Ryadnov, Yixuan Wan,NYGC ALS Consortium,Jose Norberto S. Vargas,Nicol Birsa,Towfique Raj,Jack Humphrey,Matthew Keuss,Michael Ward,Maria Secrier,Pietro Fratta
bioRxiv the preprint server for biology (2024)
Seminars in Arthritis and Rheumatism (2024): 152282
Sahba Seddighi,Yue A. Qi,Anna-Leigh Brown,Oscar G. Wilkins,Colleen Bereda,Cedric Belair,Yong-Jie Zhang,Mercedes Prudencio,Matthew J. Keuss,Aditya Khandeshi,Sarah Pickles, Sarah E. Kargbo-Hill,James Hawrot,Daniel M. Ramos,Hebao Yuan,Jessica Roberts,Erika Kelmer Sacramento,Syed I. Shah,Mike A. Nalls,Jennifer M. Colon-Mercado,Joel F. Reyes,Veronica H. Ryan,Matthew P. Nelson,Casey N. Cook,Ziyi Li,Laurel Screven,Justin Y. Kwan, Puja R. Mehta, Matteo Zanovello, Martina Hallegger,Anantharaman Shantaraman,Lingyan Ping,Yuka Koike,Bjorn Oskarsson,Nathan P. Staff,Duc M. Duong,Aisha Ahmed,Maria Secrier,Jernej Ule,Steven Jacobson, Daniel S. Reich,Jonathan D. Rohrer,Andrea Malaspina, Dennis W. Dickson,Jonathan D. Glass,Alessandro Ori,Nicholas T. Seyfried,Manolis Maragkakis,Leonard Petrucelli,Pietro Fratta,Michael E. Ward
Science Translational Medicineno. 734 (2024)
Allison Snyder,Veronica H. Ryan,James Hawrot, Sydney Lawton,Daniel M. Ramos, Y. Andy Qi, Kory R. Johnson,Xylena Reed, Nicholas L. Johnson,Aaron W. Kollasch,Megan F. Duffy,Lawren VandeVrede,J. Nicholas Cochran,Bruce L. Miller,Camilo Toro,Bibiana Bielekova,Debora S. Marks,Jennifer S. Yokoyama,Justin Y. Kwan,Mark R. Cookson,Michael E. Ward
ALZHEIMERS & DEMENTIAno. 8 (2024): 5220-5235
Jorge Gómez-Deza,Matthew Nebiyou,Mor R. Alkaslasi, Francisco M. Nadal-Nicolás, Preethi Somasundaran,Anastasia L. Slavutsky,Michael E. Ward, Wei Li,Trent A. Watkins,Claire E. Le Pichon
biorxiv(2024)
Anna Calliari,Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero,Mei Yue,Karen Jansen-West,Naeyma N. Islam,Thomas Caulfield, Bailey Rawlinson,Michael DeTure,Casey Cook,Neill R. Graff-Radford,Gregory S. Day,Bradley F. Boeve,David S. Knopman,Ronald C. Petersen,Keith A. Josephs,Björn Oskarsson,Aaron D. Gitler,Dennis W. Dickson,Tania F. Gendron,Mercedes Prudencio,Michael E. Ward,Yong-Jie Zhang,Leonard Petrucelli
Molecular Neurodegenerationno. 1 (2024): 1-5
Lorenzo Pasquini,Felipe L Pereira,Sahba Seddighi,Yi Zeng,Yongbin Wei,Ignacio Illán-Gala,Sarat C Vatsavayai,Adit Friedberg,Alex J Lee,Jesse A Brown,Salvatore Spina,Lea T Grinberg,Daniel W Sirkis,Luke W Bonham,Jennifer S Yokoyama,Adam L Boxer,Joel H Kramer, Howard J Rosen,Jack Humphrey,Aaron D Gitler,Bruce L Miller, Katherine S Pollard,Michael E Ward,William W Seeley
Brain (2024)
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作者统计
#Papers: 474
#Citation: 19013
H-Index: 69
G-Index: 124
Sociability: 8
Diversity: 0
Activity: 4
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