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个人简介
We are a research team that is trying to understand the molecular details that determine how, where, and when motor proteins transport intracellular cargo. The past thirty years of cell biology research have set the stage for us to determine the general principles that underlie the complex process of intracellular transport.
Specifically, we are interested in the mechanisms that dictate how cytoplasmic dynein and kinesin are recruited to- and activated for- cargo transport. For each project, we will be trying to answer the following questions:
How is specificity determined between motor proteins and cargo?
How are the activities of multi-motor complexes regulated?
What are the molecular consequences of neurodegenerative disease-causing mutations?
We will be approaching these questions using state of the art technologies that range from mammalian cell protein expression to cryo-EM to single molecule fluorescence assays. This integrated approach will allow us to relate how changes at the molecular level alter the structure and function of transporting motor-cargo complexes.
Specifically, we are interested in the mechanisms that dictate how cytoplasmic dynein and kinesin are recruited to- and activated for- cargo transport. For each project, we will be trying to answer the following questions:
How is specificity determined between motor proteins and cargo?
How are the activities of multi-motor complexes regulated?
What are the molecular consequences of neurodegenerative disease-causing mutations?
We will be approaching these questions using state of the art technologies that range from mammalian cell protein expression to cryo-EM to single molecule fluorescence assays. This integrated approach will allow us to relate how changes at the molecular level alter the structure and function of transporting motor-cargo complexes.
研究兴趣
论文共 75 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 19 (2024)
Sandeep Ravala, Sendi Adame-Garcia, Sheng Li,Chun-Liang Chen,Michael A. Cianfrocco, J. Silvio Gutkind,Jennifer Cash, John J. Tesmer
Biophysical journalno. 3 (2024): 152a-152a
Journal of Biological Chemistryno. 3 (2024)
Catherine A. Wilhelm,Leena Mallik, Abigail L. Kelly,Shayna Brotzman,Johnny Mendoza,Anna G. Anders,Suada Leskaj, Carmen Castillo,Brandon T. Ruotolo,Michael A. Cianfrocco,Markos Koutmos
Journal of biological chemistry/The Journal of biological chemistryno. 11 (2023): 105327-105327
Yilai Li,Quanfu Fan, Ziping Xu, Emma Rose Lee,John Cohn, Veronique Demers, Ja Young Lee,Lucy Yip,Michael A. Cianfrocco,Seychelle M. Vos
biorxiv(2023)
Le Yang, Chuteng Li, Han Liu, Rong Xiao, Benjamin Walls, Yicheng Zhang, Jiawen Zhang, Lueyu Wang, Chuck Lugai, Sujit Lakshmikanth, Nicholas Vangos,Michael Cianfrocco,Yilai Li
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2023): A236-A236
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bioRxiv the preprint server for biology (2023)
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#Papers: 73
#Citation: 1506
H-Index: 20
G-Index: 38
Sociability: 6
Diversity: 3
Activity: 42
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