Research Interests
The aim of the last years research is centered in brain senescence and Alzheimer’s disease, both in studying molecular mechanisms gated to this deleterious process as well as to study non pharmacological (exercise, caloric restriction) and pharmacological (melatonin, resveratrol, new chemical entities) strategies to ameliorate and to prevent them with a special focus on the role of sirtuin 1 in inflammaging.
As applicative follow out of its research, group is currently interested in identification of new target to achieve preventive or curative strategies by reducing inflammation, mitochondrial and endoplasmic reticulum stress, oxidative stress in pathological senescence and the crossroad with epigenetics. The research conducted in recent years by the research group has been focused primarily on the SAMP8 model (senescence accelerated mouse) strain prone to early aging and sporadic AD and in transgenic AD models.