Fungal infections are silent killers, and cause misery to millions. More die of fungal diseases than either TB or malaria. After headaches and rotten teeth, skin fungal infections are the commonest diseases on Earth. Serious fungal infections afflict the most economically productive, especially in TB, AIDS and cancer patients, having a disproportionate impact on economies. Only 30 species of fungi regularly cause disease of the 600 species that have ever caused infection in humans.