Megan Fitzgerald - Oligonucleotide Biol, Aligos Therapeut Inc

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Lack of Translation of Favorable Nonclinical Toxicology Profile of Antisense Oligonucleotide (ASO) ALG-020572 to Chronic Hepatitis B (CHB) Patients

Sandra Chang,Dinah Misner,Kusum Gupta,Gina Gratz,Jin Hong,Kha Le,Vikrant Gohil,Vivek K. Rajwanshi,Megan Fitzgerald,Felix Lai,Meenakshi Venkatraman, Min Wu,Matthew McClure,John Fry,David B. Smith,Julian A. Symons,Lawrence Blatt,Leonid Beigelman, Tse-I Lin,Sushmita Chanda

INTERNATIONAL JOURNAL OF TOXICOLOGYno. 1 (2023): 89-90

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A Potent Human PD-L1 Sirna Leads to Significant Reduction of AAV-HBV Infected Hepatocytes Via Immune Activation in Human PD-1/PD-L1 Double Knock in Mice

Jin Hong,Dawei Cai, Saul Montero,Hua Tan,Vivek Rajwanshi,Aneerban Bhattacharya,Kang Hyunsoon, Min Luo,Megan Fitzgerald,David Smith,Lawrence Blatt,Julian Symons,Leonid Beigelman

Journal of hepatology (2023): S1029-S1029

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Pharmacodynamic Durability of ALG-125755, a GalNAc-conjugated Sirna, Correlated with Total and RNA Induced Complex (RISC) Bound Sirna in Mouse Liver

Kusum Gupta,Megan Fitzgerald,Jin Hong,Cheng Kao, Cheng Liu,Kha Le,Sucheta Mukherjee,Dinah Misner,Meenakshi Venkatraman,Matt McClure,Sushmita Chanda,John Fry,David Smith,Julian Symons,Lawrence Blatt,Leonid Beigelman,Tse-I Lin

Journal of hepatology (2023): S1029-S1029

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Safety, Pharmacokinetics, and Antiviral Activity of Single Ascending Doses of ALG-125755, a GalNAc-conjugated Small Interfering RNA, in Subjects with Chronic Hepatitis B

Alina Jucov,Edward J. Gane,Megan Fitzgerald,Kha Le,Stanley Wang, Lynne Ammar, Chris Burnett,Alexei Haceatrean,Kusum Gupta, Doug Clark,Meenakshi Venkatraman,Leonid Beigelman,Lawrence Blatt,Tse-I Lin,Sushmita Chanda,Matthew McClure,John Fry

Journal of hepatology（2023）

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SUPPRESSION OF PD-L1 EXPRESSION BY A NOVEL LIVER-TARGETED siRNA LEADS TO POTENTIAL RESTORATION OF IMMUNE RESPONSES AGAINST HBV

Dawei Cai,Saul Martinez Montero,Vera Huang,Megan E. Fitzgerald,Aneerban Bhattacharya,Lawrence M. Blatt,David B. Smith,Julian A. Symons,Leonid N. Beigelman,Jin Hong

HEPATOLOGY（2022）

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The HBV Sirna, ALG-125755, Demonstrates a Favourable Nonclinical Profile and Significant and Durable Hepatitis B Surface Antigen Reductions in the AAV-HBV Mouse Efficacy Model

Megan Fitzgerald,Kusum Gupta,Kha Le,Sucheta Mukherjee,Jin Hong, Khiem Nguyen, Alfred Chen,Vivek Rajwanshi,Caroline Williams,Meenakshi Venkatraman,Matthew McClure,Sushmita Chanda,John Fry,David Smith,Julian Symons,Lawrence Blatt,Leonid Beigelman, Tse-I Lin

Journal of Hepatology（2022）

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Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of ALG-020572, a GalNAc-conjugated Antisense Oligonucleotide, in Healthy Subjects

Edward J. Gane,Man-Fung Yuen,Christian Schwabe,Min Wu,Kha Le, Jen Rito,Kusum Gupta,Christopher Westland,Felix Lai,Meenakshi Venkatraman,Megan Fitzgerald,Tse-I Lin,Lawrence Blatt,Sushmita Chanda,Matt McClure,John Fry,Kosh Agarwal

Journal of Hepatology（2022）

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IMPROVED LIVER CONCENTRATION AND ACTIVITY OF S-ANTIGEN TRANSPORT-INHIBITING OLIGONUCLEOTIDE POLYMERS

Megan Fitzgerald,Vikrant Gohil,Yuchun Nie,Jin Hong,Rajendra Pandey,Vivek K. Rajwanshi,John Cortez,Dinah Misner,Sushmita Chanda,David B. Smith,Julian A. Symons,Lawrence M. Blatt,Leonid N. Beigelman

HEPATOLOGY（2021）

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Structural Requirements for S-antigen Transport-Inhibiting Oligonucleotide Polymer Inhibition of Hepatitis B Surface Antigen Secretion

Megan Fitzgerald,Jin Hong,Rajendra Pandey,Vivek Rajwanshi,Hua Tan,Yuchun Nie,Cheng Kao,Suping Ren,John Cortez,David Smith,Julian Symons,Lawrence Blatt,Leonid Beigelman

Journal of hepatology (2020): S876-S877

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