Alzheimer’s Disease. The Huentelman lab examines Alzheimer’s disease with the use of next generation DNA and RNA sequencing and cultured brain organoids. They are interested in helping to identify an individual’s personal risk for developing the disease as early as possible in life as well as identifying new drug targets and developing new drugs. They also undertake the genomic study of phenotypic outliers – like individuals who have extremely high risk for AD but who avoid the disease for their entire life – to better understand how Alzheimer’s progresses and may be prevented.