My research is devoted to the study of the positive and negative modulation of pain transmission, with an emphasis on chronic pain. My research group is currently focusing on neuro-immune interactions in settings of chronic pain, covering a range of specific pain subtypes from neuropathic pain to cancer-induced bone pain. To date, I have published over 100 papers on pain and edited a book on synaptic plasticity in pain. In doing so, I have explained fundamental mechanisms and identified new targets in chronic pain, including protease and chemokines pathways in microglia and macrophage-mediated mechanisms. I also lead the Wolfson CARD, which groups together researchers whose work seeks to advance our understanding of sensory systems including pain, deafness, and nervous system injury, repair and regeneration.