Martin A. Lowe - Medicinal Chemistry Department, UCB

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Deconvoluting and Derisking QRS Complex Widening to Improve Cardiac Safety Profile of Novel Plasmepsin X Antimalarials

Annie Delaunois,Alvaro Cardenas,Teresa de Haro,Helga H. J. Gerets,Vitalina Gryshkova,Simon Hebeisen,Chloe Korlowski,Benoit Laleu,Martin A. Lowe,Jean-Pierre Valentin

TOXICOLOGICAL SCIENCESno. 2 (2024): 321-330

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Assessing the Interplay Between Off-Target Promiscuity, Cytotoxicity, and Tolerability in Rodents to Improve the Safety Profile of Novel Anti-Malarial Plasmepsin X Inhibitors

Helga H. J. Gerets,Annie Delaunois,Alvaro Cardenas,Reiner Class,Renaud Fleurance,Teresa de Haro,Benoit Laleu,Martin A. Lowe,Marie-Luce Rosseels,Jean-Pierre Valentin

TOXICOLOGICAL SCIENCESno. 2 (2024): 311-320

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Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life Via Molecular Property Optimization

Komei Sakata,Martin A. Lowe, Mengyang Xuan, Jeffrey Bruffaerts, Luigi P. Stasi,Benedicte Lallemand,Alvaro Cardenas,Richard D. Taylor,Lewis R. Vidler,Lloyd King,Jean-Pierre Valentin,Benoit Laleu,Teresa de Haro

ACS MEDICINAL CHEMISTRY LETTERSno. 11 (2023): 1582-1588

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Interplay between in vitro off-target pharmacological promiscuity, cytotoxicity, and in vivo tolerability in rodents to improve the safety profile of antimalarials in drug discovery

Helga Gerets,Annie Delaunois,Alvaro Cardenas,Reiner Class,Teresa De Haro Garcia,Renaud Fleurance,Martin Lowe,Marie-Luce Rosseels,Alicia Sibony,Benoit Laleu,Jean-Pierre Valentin

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2023)

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Mechanistic investigations and early derisking of QRS widening to improve cardiac safety profile of novel antimalarials

Annie Delaunois,Alvaro Cardenas,Vitalina Gryshkova,Chloe Korlowski,Pierre Bonnaillie, Nabila Chabbi, Rosana Chirico,Teresa de Haro Garcia,Benoit Laleu,Martin Lowe,Jean-Pierre Valentin

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2023)

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Sequential Photocatalytic Reactions for the Diastereoselective Synthesis of Cyclobutane Scaffolds

Mark J Deeprose,Martin Lowe,Adam Noble,Kevin I Booker-Milburn,Varinder K Aggarwal

Organic Letters（2022）

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Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Journal of medicinal chemistry（2022）

引用7浏览0WOS引用

Preclinical Cardiotoxicity Assessment: Can Stem Cell-Derived Cardiomyocytes Contribute to the 3Rs

Vitalina Gryshkova,Isabel Lushbough,Julia Roquigny,Alvaro Cardenas,Martin Lowe,Annie Delaunois,Jean-Pierre Valentin

Journal of Pharmacological and Toxicological Methods（2021）

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Fused thiophene derivatives as MEK inhibitors

Victoria E Laing,Daniel C Brookings,Rachel J Carbery,Jose Gascon Simorte,Martin C Hutchings,Barry J Langham,Martin A Lowe,Rodger A Allen,Joanne R Fetterman,James Turner,Christoph Meier,Jeff Kennedy,Mark Merriman

Bioorganic & Medicinal Chemistry Letters（2012）

引用20浏览0WOS引用

Palladium‐Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)‐α‐kainic Acid

Martin A. Lowe,Mehrnoosh Ostovar,Serena Ferrini,C. Chun Chen,Paul G. Lawrence,Francesco Fontana,Andrew A. Calabrese,Varinder K. Aggarwal

Angewandte Chemie（2011）

引用124浏览0WOS引用

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