Dr. Sajatovic's research interests have focused on neuropsychiatric outcomes of brain disorders across the life-span, including epilepsy, stroke, Alzheimer's disease, and other types of dementia and Parkinson's disease. She also has research interests in self-management of chronic health conditions such as hypertension and diabetes, health disparities, and health rating scales used in clinical trials.

Over the last two decades, Dr. Sajatovic has been the recipient of multiple research grants, including support from the National Institute of Aging (NIA), National Institute of Mental Health (NIMH), the National Institute of Nursing Research (NINR), the Centers for Disease Control and Prevention (CDC), the Ohio Department of Mental Health (ODMH), the Veterans Health Administration (VHA), the International Society for Bipolar Disorders (ISBD) as well as a variety of private foundations, and industry-sponsored clinical trials.