基本信息
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Career Trajectory
Bio
In the last 20 years my research has a primary focus on chaperones and protein folding. My group identified clusterin (CLU) as the first known secreted (extracellular) mammalian chaperone (EC). I have generated a large body of evidence to support an integrated model I proposed in which, in body fluids, CLU and other ECs inhibit protein aggregation, neutralise the toxicity of misfolded proteins and facilitate their safe disposal via receptor-mediated endocytosis and lysosomal degradation.
Skills and Expertise
Cell Culture
Apoptosis
Flow Cytometry
Confocal Microscopy
Chaperone biology
Extracellular proteostasis
Single Molecule Fluorescence
Protein Aggregation
Research Interests
Papers共 145 篇Author StatisticsCo-AuthorSimilar Experts
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Shravan K Chintala,Jinhong Pan,Sandeep Satapathy,Rebecca Condruti, Zixuan Hao,Pei-Wen Liu, Christian F O'Conner,Joseph T Barr,Mark R Wilson,Shinwu Jeong,M Elizabeth Fini
D. Chakravarty, R. Dandekar, A. Abdelhak, B. Alvarenga, G. Sowa, C. R. Zamecnik, K. C. Zorn,B. A. Cree, A. J. Green, J. L. DeRisi, S. L. Hauser, M. Wallin,
MULTIPLE SCLEROSIS JOURNAL (2023): 215-215
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Case Reports in Otolaryngology (2023): 6996215-6
Bridget Dicker, Pablo Callejas,Graham Howie,Kevin Govender,Mark Wilson,Bronwyn Tunnage, Haydn Drake,Andy Swain,Aroha Brett,Dan Spearing,Verity Todd
Jennifer West,Sandeep Satapathy,Daniel R Whiten,Megan Kelly,Nicholas J Geraghty, Emma-Jayne Proctor,Pietro Sormanni,Michele Vendruscolo,Joel N Buxbaum,Marie Ranson,Mark R Wilson
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