Our current work mostly falls into two broad areas. Some projects focus on the biology of effective immune responses, with a particular emphasis on the mechanistic origin of the connection between immune responses and systemic physiological regulation and how immune-induced physiological change is important to support immune function. Other projects focus on how specific bacterial pathogens disrupt cellular and organismal physiology to enable their own survival and cause disease. These streams tend to converge on common conserved signalling pathways and cellular mechanisms.