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Our work centers on the mechanisms and regulation of splicing. Splicing is required to remove intron sequences from pre-mRNA and create coding sequences for translation. We try to understand:
(1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions,
(2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and
(3) the coordinate regulation of splicing events in developing systems.
(1) the mechanism of action of the core components of the spliceosome, in particular the snRNAs and their rearrangements during assembly of the spliceosome and catalysis of the splicing reactions,
(2) the regulation of alternative splicing at a mechanistic level including the coupling of splicing to transcription and RNA decay mechanisms, and
(3) the coordinate regulation of splicing events in developing systems.
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论文共 168 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biologyno. 2 (2024): 149-170
bioRxiv : the preprint server for biology (2024)
Jun Yao,Hengyi Xu, Elizabeth A Ferrick-Kiddie, Ryan M Nottingham,Douglas C Wu,Manuel Ares,Alan M Lambowitz
biorxiv(2024)
biorxiv(2022)
Andrew D Bailey,Jason Talkish,Hongxu Ding,Haller Igel, Alejandra Duran, Shreya Mantripragada,Benedict Paten,Manuel Ares
Andrew D Bailey,Jason Talkish,Hongxu Ding,Haller Igel, Alejandra Duran, Shreya Mantripragada,Benedict Paten,Manuel Ares
crossref(2022)
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