Research Summary
Many patients with CKD will progress and there is an urgent need for therapies, & we showed SHROOM3 was a promising candidate where antagonizing it reduced fibrosis in kidneys carrying a common mutation (ie A- allele). However this contrasted a protective role for SHROOM3 in glomeruli, implying Shroom3-antagonism may create glomerular injury, an effect needing to be circumvented. Our work showing that different functional parts of the protein are responsible for opposing effects protective (in glomeruli) and adverse (in tubular cells), will allow specific targeting of Shroom3 as therapy for CKD.