He is a recognized investigator and mentor in the field of noninvasive cardiovascular physiology with a leadership role in developing new techniques for quantifying heart function and applying them to study disease mechanisms and guide new therapies. His proof of the saddle geometry of the mitral valve led to clarification of the diagnosis of mitral valve prolapse as a foundation for this publication on digital heart sound analysis. He is the author of nearly 200 peer-reviewed publications, and holder of patents for mitral valve repair and a new method to quantify valvular regurgitation.