Many advances in molecular neuroscience have stemmed from Dr. Snyder's identification of receptors for neurotransmitters and drugs and elucidation of the actions of psychotropic agents. He pioneered the labeling of receptors by reversible ligand binding in the identification of opiate receptors and extended this technique to all the major neurotransmitter receptors in the brain. In characterizing each new group of receptors, he also elucidated actions of major neuroactive drugs. The isolation and subsequent cloning of receptor proteins stems from the ability to label, and thus monitor, receptors by these ligand binding techniques.