Dr. Palmert conducts research in a variety of areas. He has a long-standing interest in the regulation and disorders of pubertal timing and has conducted clinical studies of precocious and delayed puberty and in parallel has directed a laboratory-based program designed to identify and understand genetic factors that regulate the onset of puberty. His interest in the regulation of pubertal timing and in male-female differences in its onset has led to the expansion of his laboratory-based program to include investigation of the bases of sex differences in the brain, including examination of the effects of sex steroids and sex chromosomes on brain structure and function as well as effects of early-life diet exposures. In the clinical realm, Dr. Palmert has conducted research focused on improving outcomes of youth with type 1 and type 2 diabetes, improving the care of transgender adolescents, and optimizing the use of resources and diagnostic tests within the endocrine clinics.