Dr. Mittleman’s research group at the Institute for Prevention of Cardiovascular Disease is actively involved in research into both the primary and secondary prevention of acute cardiovascular events. His group is actively pursuing 3 lines of research related to the prevention of cardiovascular disease. This research includes: 1. Studies of triggers of acute cardiovascular events, 2. Studies of clinical and behavioral determinants of prognosis following acute myocardial infarction, and 3. Studies of the determinants and prognosis of premature acute coronary syndromes in women. In addition to the work in preventive cardiology, Dr. Mittleman is an expert in epidemiologic methods and is one of the codevelopers of the case-crossover study design. His research interests span the application of this methodology to disciplines other than cardiovascular disease.