Research Interests
Our laboratory studies cancer cell metabolism, tumor immunology, metastasis, and responses to oxygen/nutrient deprivation in the tumor microenvironment.

Key words: hypoxia; cancer metabolism; immunology; metastasis; in vivo and ex vivo models of pancreatic, liver, and renal cancer, and sarcoma.

Research Techniques:
Generation of genetically engineered and patient derived xenotransplanted mice, CRISPR-based gene editing and genome-wide screens, ex vivo 3D organotypic culture, integrated “omics” characterization of human tumors, TCGA data mining, bioinformatics, next generation sequencing, ChIP-Seq, epigenetics, proteomics, array cGH (the Illumina SNP platform), molecular biology, biochemistry, metabolomics, NMR spectroscopy, mass spectrometry, histology, immunohistochemistry, multiplexed immunofluorescence, animal s