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Our recent research has attempted to explain how injury to an intervertebral disc can drive a degenerative process that is akin to ‘frustrated healing’. In cadaveric spines, we use a miniature pressure transducer to examine how injury to a disc (or to an adjacent vertebra) alters the mechanical environment of disc cells in ways that would affect their metabolism. We combine this technique with an optical strain measurement system to examine how disc degeneration can lead to other spinal problems including “segmental instability”, osteophytosis, apophyseal joint osteoarthritis, degenerative scoliosis, and senile kyphosis or “dowager’s hump”. Similar methods are used to investigate how injury to the cartilage of human synovial joints can lead to cartilage deterioration, and subsequently to osteoarthritis.
Our most recent concern is to explain why degenerated discs are so painful. There is increasing evidence that pain emanates from the disc periphery (outer anulus, and endplate) which is where the nerves are, and where injury most often occurs. Unfortunately, disc research is traditionally devoted to explaining age-related deterioration of the disc centre, even though this region of the disc is unlikely to painful, and is incapable of healing. A shift of focus is required: healing and pain relief should be the primary goals, not the reversal of ageing, which may well prove to be too difficult. Current research is exploring the physical consequences of disc disruption, by characterising the mechanical and biochemical micro-environment within anulus fissures. We suspect that focal reductions in pressure and proteoglycan concentration can alter cell-matrix binding, and initiate a series of pathological events including cell apoptosis, matrix degradation and re-innervation.
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Polly Lama, Jerina Tiwari, Pulkit Mutreja, Sukirti Chauhan,Ian J. Harding,Trish Dolan,Michael A. Adams,Christine Le Maitre
ANATOMY & CELL BIOLOGYno. 3 (2023): 382-393
International Discourses of Authoritarian Populismpp.49-71, (2022)
SUCHT-ZEITSCHRIFT FUR WISSENSCHAFT UND PRAXISno. 6 (2022): 345-350
Suchtno. 6 (2022): 345-350
Suchtno. 3 (2020): 165-168
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#Papers: 235
#Citation: 19570
H-Index: 71
G-Index: 138
Sociability: 6
Diversity: 1
Activity: 1
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