The study follows 59,000 black women from across the U.S. to assess risk factors for outcomes that include breast cancer, other cancers, hypertension, diabetes, obesity, uterine fibroids, systemic lupus erythematosus, sarcoidosis, and preterm birth. Risk factors assessed include behaviors and lifestyle factors, psychosocial stress, environmental factors such as urban form and air pollution, and genetic factors. During her research career, Dr. Rosenberg has carried out multiple studies of risk factors for cancers, including cancer of the breast, cervix, and colon, and for myocardial infarction. Particular interests have been the health effects of oral and injectable contraceptives and of noncontraceptive estrogens. Several important hypotheses have been raised by her studies: that alcohol consumption increases the incidence of breast cancer and that use of nonsteroidal anti-inflammatory drugs decreases the incidence of large bowel cancer. Both hypotheses were subsequently confirmed in numerous studies. Dr. Rosenberg is the author of over 400 scientific papers.