McAlary Luke - Illawarra Health and Medical Research Institute, University of Wollongong

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职业迁徙

个人简介

I am a researcher who is trying to untangle and understand the causes of motor neuron disease. My research involves both cause and cure for MND, with a particular focus on the hallmark protein aggregation that is observed in this disease.

研究兴趣

论文共 44 篇作者统计合作学者相似作者

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Evaluating Protein Cross-Linking As a Therapeutic Strategy to Stabilize SOD1 Variants in a Mouse Model of Familial ALS

Md Amin Hossain,Richa Sarin,Daniel P. Donnelly,Brandon C. Miller,Alexandra Weiss,Luke McAlary,Svetlana V. Antonyuk,Joseph P. Salisbury, Jakal Amin,Jeremy B. Conway,Samantha S. Watson,Jenifer N. Winters,Yu Xu,Novera Alam, Rutali R. Brahme, Haneyeh Shahbazian,Durgalakshmi Sivasankar, Swathi Padmakumar, Aziza Sattarova, Aparna C. Ponmudiyan, Tanvi Gawde, David E. Verrill,Wensheng Yang, Sunanda Kannapadi,Leigh D. Plant,Jared R. Auclair,Lee Makowski,Gregory A. Petsko,Dagmar Ringe,Nathalie Y. R. Agar,David J. Greenblatt,Mary Jo Ondrechen,Yunqiu Chen,Justin J. Yerbury,Roman Manetsch,S. Samar Hasnain,Robert H. Brown Jr, Jeffrey N. Agar

PLOS BIOLOGYno. 1 (2024)

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High-content Analysis of Proteostasis Capacity in Cellular Models of Amyotrophic Lateral Sclerosis (ALS)

Isabella A. Lambert-Smith, Victoria K. Shephard,Luke Mcalary,Justin J. Yerbury,Darren N. Saunders

Scientific Reportsno. 1 (2024)

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Amyloidogenic Regions in Beta-Strands II and III Modulate the Aggregation and Toxicity of SOD1 in Living Cells

Luke McAlary,Jeremy R. Nan, Clay Shyu,Mine Sher,Steven S. Plotkin,Neil R. Cashman

Open Biologyno. 6 (2024)

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RNA-binding Properties Orchestrate TDP-43 Homeostasis Through Condensate Formation in Vivo

Natalie M. Scherer,Cindy Maurel,Matthew S. Graus,Luke Mcalary, Grant Richter,Rowan A. W. Radford,Alison Hogan,Emily K. Don,Albert Lee,Justin Yerbury,Mathias Francois,Roger S. Chung,Marco Morsch

NUCLEIC ACIDS RESEARCHno. 9 (2024): 5301-5319

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Rapid Classification of a Novel ALS-causing I149S Variant in Superoxide Dismutase-1

Victoria K. Shephard,Mikayla L. Brown,Bryony A. Thompson, Alisha Harpur,Luke Mcalary

Amyotrophic lateral sclerosis and frontotemporal degeneration/Amyotrophic lateral sclerosis & frontotemporal degenerationpp.1-7, (2024)

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Tryptophan Residues in TDP-43 and SOD1 Modulate the Cross-Seeding and Toxicity of SOD1

Edward Pokrishevsky,Michele G. DuVal,Luke McAlary,Sarah Louadi,Silvia Pozzi,Andrei Roman,Steven S. Plotkin,Anke Dijkstra,Jean-Pierre Julien,W. Ted Allison,Neil R. Cashman

JOURNAL OF BIOLOGICAL CHEMISTRYno. 5 (2024)

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ALS-linked CCNF Variant Disrupts Motor Neuron Ubiquitin Homeostasis

Natalie E. Farrawell,Monique Bax,Luke McAlary,Jessie McKenna,Simon Maksour,Dzung Do-Ha,Stephanie L. Rayner,Ian P. Blair,Roger S. Chung,Justin J. Yerbury,Lezanne Ooi,Darren N. Saunders

Human molecular genetics online/Human molecular geneticsno. 14 (2023): 2386-2398

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Protocol for the Generation and Automated Confocal Imaging of Whole Multi-Cellular Tumor Spheroids

Benjamin Genenger,Luke Mcalary,Jay R. Perry,Bruce Ashford,Marie Ranson

STAR protocolsno. 2 (2023): 102331-102331

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Assessment of Protein Inclusions in Cultured Cells Using Automated Image Analysis

Luke Mcalary, Victoria K. Shephard,Mine Sher,Lauren J. Rice,Justin J. Yerbury,Neil R. Cashman,Steven S. Plotkin

STAR protocols（2022）

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Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity

Mikayla L. Brown,Luke McAlary,Jeremy S. Lum,Natalie E. Farrawell,Justin J. Yerbury

ACS chemical neuroscience（2022）

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