Thanks to my medical background and my international collaborations I was able to make important research contributions to the field of intracellular protein transport and diseases related to misfunctions of it. My laboratory identified the LAMTOR complex and in addition, together with my team and my collaborators, we could identify 5 essential genes in diseases where intracellular transport functions were affected or lysosomal signaling. I have made extensive efforts to translate cell biology into the context of understanding and eventually treating diseases together with clinicians, e.g., the LAMTOR related diseases (Bohn et al., Nat Med 2007, Scheffler et al., Nat Comm 2014, Taub et al., J Cell Sci 2012).