He invented the “Extracorporeal CO2 Removal” and promoted the “baby lung” (1980’s) and mechanical power concepts (2016). He has previously served as President for the Italian National Society of Anesthesia, and Intensive Care, the European Society of Intensive Care, and the World Federation of Societies of Intensive and Critical Care Medicine. His research focuses on the pathophysiology and treatment of acute respiratory failure, sepsis and acid base disorders. He has published more than 400 research articles in peer reviewed journals. He is Honorary Member of the German Society of Anesthesiology and Intensive Care, Fellow of the Royal College of Physicians and was awarded with the Life Time Achievement Award by the American Society of Anesthesiology, the American Society of Critical Care Medicine and the European Society of Intensive Care and the French Society of Intensive Care.