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The sensory and cognitive functions of the brain depend on 100 billion neurons, woven into intricate and complex networks. Neurons and networks transmit information through ~100 trillion neuronal contacts known as chemical synapses. Synaptic transmission and plasticity are crucial for normal brain function, but inevitably aberrant in devastating neurological diseases, many of which have their roots in dysregulated development of synaptic structure and function. Guided by this overarching vision, our lab focuses our research endeavours on: (A) the understanding of the basic principles underlying synaptic function and morphology in the critical period of brain development with auditory brainstem (i.e. the calyx of Held) as the main model; and (B) the transformation of our discoveries into innovative strategies for mitigating and curing neurodevelopmental disorders using cerebellar circuits in transgenic mouse models and their sensorimotor gating behavioural phenotypes. By identifying novel molecular substrates and specific druggable targets using both mouse models and clinical data sets, we are developing ion channel agonists and antagonists as new molecular medicine for potential clinical interventions of neurodevelopmental disorders and neonatal neurotoxicity.
The sensory and cognitive functions of the brain depend on 100 billion neurons, woven into intricate and complex networks. Neurons and networks transmit information through ~100 trillion neuronal contacts known as chemical synapses. Synaptic transmission and plasticity are crucial for normal brain function, but inevitably aberrant in devastating neurological diseases, many of which have their roots in dysregulated development of synaptic structure and function. Guided by this overarching vision, our lab focuses our research endeavours on: (A) the understanding of the basic principles underlying synaptic function and morphology in the critical period of brain development with auditory brainstem (i.e. the calyx of Held) as the main model; and (B) the transformation of our discoveries into innovative strategies for mitigating and curing neurodevelopmental disorders using cerebellar circuits in transgenic mouse models and their sensorimotor gating behavioural phenotypes. By identifying novel molecular substrates and specific druggable targets using both mouse models and clinical data sets, we are developing ion channel agonists and antagonists as new molecular medicine for potential clinical interventions of neurodevelopmental disorders and neonatal neurotoxicity.
研究兴趣
论文共 107 篇作者统计合作学者相似作者
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JOURNAL OF PHYSIOLOGY-LONDONno. 4 (2024): 539-540
NATURE (2024)
Li-Na Gong,Han-Wei Liu,Ke Lai,Zhen Zhang, Lin-Fei Mao, Zhen-Qi Liu,Ming-Xian Li,Xin-Lu Yin,Min Liang,Hai-Bo Shi,Lu-Yang Wang,Shan-Kai Yin
The Journal of neuroscience the official journal of the Society for Neuroscience (2024)
Ze-Jie Lin,Xue Gu, Wan-Kun Gong, Mo Wang,Yan-Jiao Wu,Qi Wang,Xin-Rong Wu, Xin-Yu Zhao,Michael X Zhu,Lu-Yang Wang,Quanying Liu,Ti-Fei Yuan,Wei-Guang Li,Tian-Le Xu
The Journal of clinical investigation (2024)
Ze-Jie Lin,Xue Gu,Wan-Kun Gong, Mo Wang,Yan-Jiao Wu,Qi Wang,Xin-Rong Wu, Xin-Yu Zhao,Michael X. Zhu,Lu-Yang Wang, Quanying Liu,Ti-Fei Yuan,Wei-Guang Li,Tian-Le Xu
crossref(2024)
The Journal of physiologyno. 4 (2024): 539-540
crossref(2024)
Navroop K. Dhaliwal, Octavia Yifang Weng,Xiaoxue Dong,Afrin Bhattacharya,Mai Ahmed, Nishimura Haruka,Wendy W. Y. Choi, Aditi Aggarwal,Bryan W. Luikart,Qiang Shu,Xuekun Li,Michael D. Wilson,Jason Moffat,Lu-Yang Wang,Julien Muffat,Yun Li
Cell reportsno. 5 (2024): 114173-114173
Claire E Coupland, Ryan Karimi,Stephanie A Bueler,Yingke Liang,Gautier M Courbon,Justin M Di Trani,Cassandra J Wong, Rayan Saghian,Ji-Young Youn,Lu-Yang Wang,John L Rubinstein
Science (New York, NY)no. 6705 (2024): 168-174
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作者统计
#Papers: 106
#Citation: 6741
H-Index: 39
G-Index: 82
Sociability: 6
Diversity: 0
Activity: 1
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