基本信息
浏览量:3
职业迁徙
个人简介
The second messenger molecule cAMP, which modulates cell growth and differentiation in organisms from bacteria to higher eukaryotes, is produced by adenylyl cyclases. Mammals possess two distinct classes of adenylyl cyclase, the hormone-responsive, transmembrane adenylyl cyclases (tmAC) and the bicarbonate-regulated Soluble Adenylyl Cyclase (sAC). In collaboration with Dr. Jochen Buck, Dr. Levin was the first to purify and clone mammalian sAC and demonstrate its regulation by bicarbonate ions. Because bicarbonate is in nearly instantaneous equilibrium with carbon dioxide and intracellular pH due to the ubiquitous presence of carbonic anhydrases, sAC is poised to respond to changes in carbon dioxide production and intracellular pH and thereby sense the metabolic state of the cell.
In eukaryotic cells, second messengers, such as cAMP, can play multiple, disparate roles within in a single cell. This is achieved by compartmentalization into independently regulated signaling microdomains distributed throughout the cell. For example, in a single cell, sAC-generated cAMP modulates distinct effectors from tmAC-generated cAMP. We have shown sAC is distributed to intracellular sites containing cAMP effectors; therefore, it seems to represent the source of second messenger for intracellular cAMP signaling microdomains.
In eukaryotic cells, second messengers, such as cAMP, can play multiple, disparate roles within in a single cell. This is achieved by compartmentalization into independently regulated signaling microdomains distributed throughout the cell. For example, in a single cell, sAC-generated cAMP modulates distinct effectors from tmAC-generated cAMP. We have shown sAC is distributed to intracellular sites containing cAMP effectors; therefore, it seems to represent the source of second messenger for intracellular cAMP signaling microdomains.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Natalia del R. Rivera Sanchez,Carla Ritagliati,Gregory S. Kopf, Steve Kretschmer,Jochen Buck,Lonny R. Levin
Molecular Aspects of Medicine (2024): 101281
Journal of chemical information and modelingno. 9 (2023): 2828-2841
Frontiers in cell and developmental biology (2023): 1234221
Frontiers in Cell and Developmental Biology (2023): 1160154
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeuticsno. 5 (2023): 317-323
Michael Miller,Thomas Rossetti,Jacob Ferreira,Lubna Ghanem,Melanie Balbach,Navpreet Kaur,Lonny R. Levin,Jochen Buck, Maria Kehr,Sandrine Coquille,Joop van den Heuvel,Clemens Steegborn,Makoto Fushimi,Efrat Finkin-Groner,Robert W. Myers,Stacia Kargman,Nigel J. Liverton,David J. Huggins,Peter T. Meinke
FRONTIERS IN PHYSIOLOGY (2022)
加载更多
作者统计
#Papers: 160
#Citation: 10654
H-Index: 51
G-Index: 102
Sociability: 6
Diversity: 4
Activity: 43
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn