The goal of Dr. Scott's work is to understand the factors that regulate gene expression levels and influence the regulatory environment in T2D-related tissues, including muscle, adipose and pancreatic islets. Dr. Scott's research focuses on variability in mRNA, miRNA, metabolites and methylation levels by sex, T2D-related phenotypes and genotypes (eQTLs, miQTL, meQTL) within bulk skeletal muscle and subcutaneous adipose tissue data. Within muscle single cell data, she works to understand what causes differences in cell-type expression levels (RNA-seq) and regulatory region accessibility (ATAC-Seq) by sex, T2D-related phenotypes and genotype. Dr. Scott leads studies to identify genetic variants that increase the risk of common diseases, including type 2 diabetes, bipolar disorder and schizophrenia, with emphasis on analysis in African American sample. She develops methods to identify disease-associated variants and analyze experimental data.